fever is systemic infection with the bacterium salmonella enterica serotype typhi and it continues to be a
worldwide major health problem. Today enteric fever is causing diagnostic and
therapeutic challenge for physicians in Indian subcontinent and south-east Asia
due to its changing mode of presentation as well as the occurrence of multidrug
resistance. This review focuses on recent atypical clinical presentation, newer
diagnostic test and changing pattern of multidrug resistant enteric fever
(MDREF) and its therapeutic options.