This research study examined if relationship exists between the management of managerial stress and organizational performance, with reference to selected private and public hospitals in Port Harcourt, Nigeria. The management of managerial stress is a critical factor that needs a strategic attention in both home, family and workplace environment relationships, since it is revealed to impact on individual and overall organizational performance. The study employed survey research design and cross-sectional approach. A total of 120 statistically selected respondents were derived from 30 statistically selected private and public hospitals in Port Harcourt. The validity and reliability tests of data collection instrument were conducted, achieving consistency score of 0.814 Cronbach’s Alpha coefficient. Copies of Likert 5-type scale measure and structured questionnaire were distributed. After data cleaning, 108 copies were found fit for use in the analysis. The generated data were descriptively and inferentially analyzed, using Pearson’s correlation and multiple regression techniques. The study revealed the existence of relationship between the major study variables, and the extent to which the managerial stress management can cub low productivity and enhance organizational performance. Severe stress is psychologically hazardous, mentally harmful and impacts negatively on organizational performance. Moderate stress as revealed tends to be potentially useful in organizational performance. Maintenance of appropriate job design and flexible working hour polices, amongst others, were recommended in respective functional areas.