The original objectives were stated as follows: a study of the mechanism of conversion of fibrinogen to fibrin, with emphasis on the properties of intermediates are presented. A delineation of the conditions under which nucleic acid exists as a gel, and a description of the properties of its gels, and a description of the properties of gels formed from denatured proteins are described. The mechanical properties of other gel-forming systems, especially solutions of gelatin and cellulose derivatives, in both gelatinous and non-gelatinous states were in vestigated. The internal flexibility of protein molecules in both native and denatured states, iscoelastic measurements in dilute solu tions are discussed. Similar investigations of synthetic polymers of simpler structure to aid in interpreting the results of measurements on proteins, and similar investigations of other biological macromolecules were performed.