Current technology-based efforts are focusing on a nanotechnology approach to sorbent development for air purification applications. Metal-organic frameworks (MOFs) are a novel class of materials that allow for specific functionalities to be designed directly into a porous framework. This report summarizes the evaluation of MOFs impregnated with various chemicals for enhanced reactivity. Specifically, MOF-5 (IRMOF-l) was impregnated with citric acid, copper acetate, copper oxide, and triethylenediamine (TEDA) and evaluated for porosity, moisture uptake, and TIC removal capabilities. Results indicate that most of the impregnated MOFs suffered substantial loss in porosity; however, some exhibited substantial chemical removal capabilities. New impregnation techniques and different impregnants will be investigated based on the results of the study.