The training grant has two goals. The first goal is to integrate the students from Hampton University (HU) into the Prostate Center through research, lectures, seminars, and clinical exposure. The second goal is to attract talented HU students into the graduate prostate cancer program at GU. To achieve these goals, the training program is divided into two parts. Part I (8-12 weeks) consists of a mentored summer research experience at GU in the laboratory of a training faculty and attendance of lectures, seminars, and journal club. Attendance on clinical rounds and at clinical conferences on prostate cancer allows the trainees to follow prostate cancer patients through treatment. In addition, the trainees attend the weekly graduate school preparation session and are scheduled to take the GRE general and subject tests. During the academic year, part II consists of an educational and research component that enhances the prostate cancer training of the students through enrollment in HU BIO408 Research Problems. During the third year of funding, four students from HU conducted research on the mechanism of action of novel drugs that sensitize prostate tumors to radiation treatment; on the role of BRCA1 and oxidative stress in prostate cancer; on the role of the hippo-yap pathway in the proliferation of prostate cancer; and on the metabolomic profile of prostate cancer. The students are currently enrolled in the Research Problems course and scheduled to take the GRE exam.