NASA's investment and research in aviation has led to new technologies and concepts that make aircraft more efficient and environmentally friendly. One aircraft design operational concept is the reduction of cruise speed to reduce fuel burned during a mission. Although this is not a new idea, it was used by all of the contractors involved in a 2008 NASA sponsored study that solicited concept and technology ideas to reduce environmental impacts for future subsonic passenger transports. NASA is currently improving and building new analysis capabilities to analyze advanced concepts. To test some of these new capabilities, a transonic truss braced wing configuration was used as a test case. This paper examines the effects due to changes in the design cruise speed and other tradeoffs in the design space. The analysis was baselined to the Boeing SUGAR High truss braced wing concept. An optimization was run at five different design cruise Mach numbers. These designs are compared to provide an initial assessment space and the parameters that should be considered when selecting a design cruise speed. A discussion of the design drivers is also included. The results show that the wing weight in the current analysis has more influence on the takeoff gross weight than expected. This effect caused lower than expected wing sweep angle values for higher cruise speed designs.