The choice of ideal local anaesthetic agent for spinal anaesthesia is therefore crucial in the ambulatory setting. Lignocaine is
associated with a high incidence of transient neurological symptoms, and bupivacaine produces sensory and motor blocks for
a prolonged duration.
Aims: This study was designed to compare preservative-free 2-chloroprocaine 40 mg with hyperbaric bupivacaine 15 mg for
spinal anaesthesia in an elective ambulatory setting.
Methodology: After approval from the institutional ethics committee, this prospective double-blind interventional study was
conducted in 64 patients undergoing spinal anaesthesia. Informed consent was obtained and the study sample was divided into
two groups. Group A-1%2-chloroprocaine(n=32), Group B-0.5% hyperbaric bupivacaine(n=32).For statistical analysis, unpaired
T-test and chi-square test were used.
Results: The onset characteristics of the sensory block were similar between the groups. However, the onset of motor block,
regression characteristics did show a different profile between the two groups. The time for complete regression of sensory
blockade to S2 in the 2-CP group was less that of the bupivacaine group (147 min vs 252 min, respectively, p value<0.0001),
a difference of 95 minutes. Similarly, the duration of the motor & sensory block was significantly shorter in the chloroprocaine
group. The time for ambulation was 184 minutes in chloroprocaine group compared to 280 minutes in the bupivacaine group(p
value<0.0001).
Conclusions: 40 mg of plain 1% 2-chloroprocaine proved to be comparable with 15 mg of 0.5% hyperbaric bupivacaine in terms
of onset of sensory block. But showed faster recovery from anaesthesia implying superior suitability for outpatient surgeries.
Key Words: Infra-umbilical surgeries, 2-chloroprocaine, Bupivacaine, Spinal Anaesthesia, Sensory Block, Motor Block.

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