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This article is from Journal of Epidemiology and Community Health , volume 65 . Abstract Background: A/H1N1, more commonly referred to as swine flu, emerged in Mexico in spring 2009. It rapidly spread across the world and was classed as a global pandemic on 11 June 2009. Objective: To analyse UK newsprint coverage of the swine flu pandemic. Methods: Content analysis of 2374 newsprint articles published in eight UK national newspapers between 1 March 2009 and 28 February 2010. Results: Newsprint...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171979
PubMed Central
by Hoy, C. L.; Gamm, U. A.; Sterenborg, H. J. C. M.; Robinson, D. J.; Amelink, A.
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This article is from Biomedical Optics Express , volume 3 . Abstract Multi-diameter single fiber reflectance (MDSFR) spectroscopy enables quantitative measurement of tissue optical properties, including the reduced scattering coefficient and the phase function parameter γ. However, the accuracy and speed of the procedure are currently limited by the need for co-localized measurements using multiple fiber optic probes with different fiber diameters. This study demonstrates the use of a coherent...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469986
PubMed Central
by Libiakova, Michaela; Flokova, Kristyna; Novak, Ondrej; Slovakova, L'udmila; Pavlovic, Andrej
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This article is from PLoS ONE , volume 9 . Abstract The trap of the carnivorous plant Venus flytrap (Dionaea muscipula) catches prey by very rapid closure of its modified leaves. After the rapid closure secures the prey, repeated mechanical stimulation of trigger hairs by struggling prey and the generation of action potentials (APs) result in secretion of digestive fluid. Once the prey's movement stops, the secretion is maintained by chemical stimuli released from digested prey. We investigated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4143254
PubMed Central
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This article is from Annals of The Royal College of Surgeons of England , volume 94 . Abstract INTRODUCTION: The preliminary results of a pyrocarbon interpositional radiocarpal implant in a small cohort of patients were reviewed. As it is currently only a limited release product, we describe to potential users early complications and negative outcomes. METHODS: Patients were assessed using pain levels, ranges of motion, grip strength, type of and time to return to work as well as pre-operative...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954246
PubMed Central
by Mora-Lee, Silvia; Sirerol-Piquer, Ma Salome; Gutierrez-Perez, Maria; Lopez, Tania; Casado-Nieto, Mayte; Jauquicoam, Carlos; Abizanda, Gloria; Romaguera-Ros, Miriam; Gomez-Pinedo, Ulises; Prosper, Felipe; Garcia-Verdugo, Jose-Manuel
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This article is from Journal of Inflammation (London, England) , volume 8 . Abstract Background: Stroke models are essential tools in experimental stroke. Although several models of stroke have been developed in a variety of animals, with the development of transgenic mice there is the need to develop a reliable and reproducible stroke model in mice, which mimics as close as possible human stroke. Methods: BALB/Ca-RAG2-/-γc-/- mice were subjected to cauterization or thrombosis stroke model and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221623
PubMed Central
by Dalfardi, Behnam; Esnaashary, Mohammad Hosein; Yarmohammadi, Hassan
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This article is from Infectious Diseases of Poverty , volume 3 . Abstract Ibn Sina (980–1037 AD), known by his full name Abu Ali al-Hussain ibn Abdallah ibn Sina and the Latin name ‘Avicenna’, was a Persian scholar who is primarily remembered for his contributions to the science of medicine. He authored Al-Qanun fi al-Tibb (The Canon of Medicine). Sections of his work are devoted to detailed descriptions of a number of infectious illnesses, particularly rabies. Avicenna described rabies...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933285
This article is from Dialogues in Clinical Neuroscience , volume 9 . Abstract Evidence suggests that depression in multiple sclerosis (MS) is largely biologically mediated by some of the same processes involved in the immunopathogenesis of this neurologic disease. In particular, the increase in proinflammatory cytokines, activation of the hypothalamic-pituitary-adrenal (HPA) axis, and reduction in neurotrophic factors that occur in MS may each account for the increased rate of depression seen...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181849
PubMed Central
by Tatsuke, Tsuneyuki; Zhu, Li; Li, Zhiqing; Mitsunobu, Hitoshi; Yoshimura, Kaito; Mon, Hiroaki; Lee, Jae Man; Kusakabe, Takahiro
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This article is from PLoS ONE , volume 9 . Abstract Piwi proteins are part of a superfamily of Argonaute proteins, which are one of the core components of the RNA silencing pathway in many eukaryotes. Piwi proteins are thought to repress the transposon expression both transcriptionally and post-transcriptionally. Recently, Drosophila melanogaster Piwi was recently reported to associate with chromatin and to interact directly with the Heterochromatin Protein 1 (HP1a). However, similar...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956929
PubMed Central
by Ghoorah, Anisah W.; Devignes, Marie-Dominique; Smail-Tabbone, Malika; Ritchie, David W.
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This article is from Nucleic Acids Research , volume 42 . Abstract Comparing, classifying and modelling protein structural interactions can enrich our understanding of many biomolecular processes. This contribution describes Kbdock (http://kbdock.loria.fr/), a database system that combines the Pfam domain classification with coordinate data from the PDB to analyse and model 3D domain–domain interactions (DDIs). Kbdock can be queried using Pfam domain identifiers, protein sequences or 3D...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964971
PubMed Central
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This article is from PLoS ONE , volume 9 . Abstract Germline and somatic biallelic mutations of the Tuberous sclerosis complex (TSC) 1 and TSC2 gene products cause TSC, an autosomal dominant multifocal hamartomatosis with variable neurological manifestations. The consequences of TSC1 or TSC2 loss in cells of hematopoietic origin have recently started to be unveiled in mice and showed to hinder the development of proper T cell immunity. To date, the consequences of germline TSC1 mutations and/or...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954840
PubMed Central
by Biffi, Emilia; Regalia, Giulia; Menegon, Andrea; Ferrigno, Giancarlo; Pedrocchi, Alessandra
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This article is from PLoS ONE , volume 8 . Abstract It is known that cell density influences the maturation process of in vitro neuronal networks. Neuronal cultures plated with different cell densities differ in number of synapses per neuron and thus in single neuron synaptic transmission, which results in a density-dependent neuronal network activity. Although many authors provided detailed information about the effects of cell density on neuronal culture activity, a dedicated report of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3873984
PubMed Central
by Yanardag, Halil; Tetikkurt, Cuneyt; Bilir, Muammer; Demirci, Sabriye; Iscimen, Aydin
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This article is from Multidisciplinary Respiratory Medicine , volume 8 . Abstract Background: Sarcoidosis is a systemic disease characterized by the formation of noncaseating granulomas in various tissues. Cutaneous involvement occurs in 20 to 35 percent of the patients and may be the initial manifestation of the disease. Our study was performed to discriminate the clinical, laboratory, and prognostic differences between patients with specific and nonspecific cutaneous involvement. The second...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614473
PubMed Central
by Gliga, Anda R; Skoglund, Sara; Odnevall Wallinder, Inger; Fadeel, Bengt; Karlsson, Hanna L
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This article is from Particle and Fibre Toxicology , volume 11 . Abstract Background: Silver nanoparticles (AgNPs) are currently one of the most manufactured nanomaterials. A wide range of toxicity studies have been performed on various AgNPs, but these studies report a high variation in toxicity and often lack proper particle characterization. The aim of this study was to investigate size- and coating-dependent toxicity of thoroughly characterized AgNPs following exposure of human lung cells...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933429
PubMed Central
by Tang, Mengjie; Tian, Yihao; Li, Doulin; Lv, Jiawei; Li, Qun; Kuang, Changchun; Hu, Pengchao; Wang, Ying; Wang, Jing; Su, Ke; Wei, Lei
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This article is from PLoS ONE , volume 9 . Abstract Acute lung injury (ALI) is an inflammatory disorder associated with reduced alveolar-capillary barrier function and increased pulmonary vascular permeability. Vasodilator-stimulated phosphoprotein (VASP) is widely associated with all types of modulations of cytoskeleton rearrangement-dependent cellular morphology and function, such as adhesion, shrinkage, and permeability. The present studies were conducted to investigate the effects and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106849
PubMed Central
by Deepak, Parakkal; Bruining, David H.
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This article is from Gastroenterology Report , volume 2 . Abstract Radiographical modalities have become important diagnostic tools in cases of ulcerative colitis (UC). Imaging can be used non-invasively to determine the extent of involvement, severity of disease and to detect disease-related complications and extra-intestinal inflammatory bowel disease (IBD) manifestations. While abdominal X-rays and barium enemas still retain their relevance in specific clinical settings, the use of computed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124269
PubMed Central
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This article is from Dialogues in Clinical Neuroscience , volume 11 . Abstract More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. In both developed and developing nations, Alzheimer's disease has had tremendous impact on the affected individuals, caregivers, and society. The etiological factors, other than older age and genetic susceptibility, remain to be determined. Nevertheless, increasing evidence strongly points to the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181909
PubMed Central
by Friendship, Katelyn A.; Furgal, Chris M.
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This article is from International Journal of Circumpolar Health , volume 71 . Abstract Objectives: This project aimed to gain better understandings of northern Indigenous risk perception related to food safety and to identify the role that Indigenous knowledge (IK) plays in risk management processes to support more effective and culturally relevant benefit-risk (B-R) management strategies. Study design: The project used an exploratory qualitative case study design to investigate the role and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417550
PubMed Central
by Ferreira, Amanda Ribeiro; Singh, Balwan; Cabrera-Mora, Monica; Magri De Souza, Alana Cristina; Queiroz Marques, Maria Teresa; Porto, Luis Cristovao Sobrino; Santos, Fatima; Banic, Dalma Maria; Calvo-Calle, J. Mauricio; Oliveira-Ferreira, Joseli; Moreno, Alberto; Da Costa Lima-Junior, Josue
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This article is from PLoS ONE , volume 9 . Abstract The development of modular constructs that include antigenic regions targeted by protective immune responses is an attractive approach for subunit vaccine development. However, a main concern of using these vaccine platforms is how to preserve the antigenic identity of conformational B cell epitopes. In the present study we evaluated naturally acquired antibody responses to a chimeric protein engineered to contain a previously defined...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141821
PubMed Central
by Rowles, Thomas A
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This article is from BMC Surgery , volume 14 . Abstract Contributing reviewers: The editors of BMC Surgery would like to thank all our reviewers who have contributed their time to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893518
PubMed Central
by Gatsos, Xenia; Steer, David L; Junaid, Thamradeen A; Smith, A Ian; Adler, Ben; Albert, M John
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This article is from BMC Microbiology , volume 12 . Abstract Background: Campylobater jejuni, a major foodborne diarrhoeal pathogen is reported to produce a number of cytotoxins of which only a cytolethal distending toxin (CDT) has been characterised so far. One or more additional cytotoxins other than CDT, including a Chinese hamster ovary (CHO) cell active, Vero cell inactive cytotoxin, may mediate inflammatory diarrhoea. Our objective was to develop a method to enrich and thus partially...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541203
PubMed Central
by Solera, Dafne
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This article is from BMC Cancer , volume 14 . Abstract Contributing reviewers: The editors of BMC Cancer would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909450
PubMed Central
by Shaffer, John R.; Polk, Deborah E.; Wang, Xiaojing; Feingold, Eleanor; Weeks, Daniel E.; Lee, Myoung-Keun; Cuenco, Karen T.; Weyant, Robert J.; Crout, Richard J.; McNeil, Daniel W.; Marazita, Mary L.
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This article is from G3: Genes|Genomes|Genetics , volume 4 . Abstract The etiology of chronic periodontitis clearly includes a heritable component. Our purpose was to perform a small exploratory genome-wide association study in adults ages 18–49 years to nominate genes associated with periodontal disease−related phenotypes for future consideration. Full-mouth periodontal pocket depth probing was performed on participants (N = 673), with affected status defined as two or more sextants with...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931564
PubMed Central
by Tabrizizadeh, M.; Reuben, J.; Khalesi, M.; Mousavinasab, M.; Ezabadi, MK. Ghane
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This article is from Journal of Dentistry (Tehran, Iran) , volume 7 . Abstract Objective:: Better understanding of the furcation anatomy may serve to decrease the risk of root perforation. The purpose of this study was to measure the thickness of root walls in the danger zone in mandibular first molars. Materials and Methods:: The roots of 53 extracted human mandibular first molars were sectioned in the horizontal plane 4 mm below the orifice of the mesial and distal root canals. For each cut...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3184764
PubMed Central
by Wei, Shu-Chen; Tan, Yan-Yin; Weng, Meng-Tzu; Lai, Liang-Chuan; Hsiao, Jen-Hao; Chuang, Eric Y.; Shun, Chia-Tung; Wu, Deng-Cheng; Kao, Ai-Wen; Chuang, Chiao-Shung; Ni, Yen-Hsuan; Shieh, Ming-Jium; Tung, Chien-Chih; Chen, Yun; Wang, Cheng-Yi; Xavier, Ramnik J.; Podolsky, Daniel K.; Wong, Jau-Min
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This article is from PLoS ONE , volume 9 . Abstract Background & Aims: To date, only one gene (TNFSF15) has been identified and validated as a Crohn’s disease (CD)-associated gene in non-Caucasian populations. This study was designed to identify novel CD-associated single nucleotide polymorphisms (SNPs)/genes and to validate candidate genes using a functional assay. Methods: SNPs from 16 CD patients and 16 age- and sex-matched control patients were analyzed using Illumina platform...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063938
PubMed Central
by Kirkpatrick, John P.; Light, Kim L.; Walker, Robyn M.; Georgas, Debra L.; Antoine, Phillip A.; Clough, Robert W.; Cozart, Heidi B.; Yin, Fang-Fang; Yoo, Sua; Willett, Christopher G.
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This article is from Frontiers in Oncology , volume 3 . Abstract Purpose/Objective: While our department is heavily invested in computer-based treatment planning, we historically relied on paper-based charts for management of Radiation Oncology patients. In early 2009, we initiated the process of conversion to an electronic medical record (EMR) eliminating the need for paper charts. Key goals included the ability to readily access information wherever and whenever needed, without compromising...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3629369
PubMed Central
by Bonelli, Michael; Goschl, Lisa; Bluml, Stephan; Karonitsch, Thomas; Steiner, Carl-Walter; Steiner, Gunter; Smolen, Josef S; Scheinecker, Clemens
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This article is from Arthritis Research & Therapy , volume 16 . Abstract Introduction: Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease, which can affect different organs. Increased proportions of CD4+CD25-Foxp3+ T cells have been described in SLE patients. The exact role of this cell population in SLE patients still remains unclear. We therefore analyzed this T cell subset in a large cohort of SLE patients with different organ manifestations. Methods: Phenotypic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060257
PubMed Central
by Arensburger, Peter; Hice, Robert H; Wright, Jennifer A; Craig, Nancy L; Atkinson, Peter W
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This article is from BMC Genomics , volume 12 . Abstract Background: The piRNA pathway has been shown in model organisms to be involved in silencing of transposons thereby providing genome stability. In D. melanogaster the majority of piRNAs map to these sequences. The medically important mosquito species Aedes aegypti has a large genome size, a high transposon load which includes Miniature Inverted repeat Transposable Elements (MITES) and an expansion of the piRNA biogenesis genes. Studies of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3259105
PubMed Central
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This article is from Frontiers in Psychology , volume 5 . Abstract Recent research with moral dilemmas supports dual-process model of moral decision making. This model posits two different paths via which people can endorse utilitarian solution that requires personally harming someone in order to achieve the greater good (e.g., killing one to save five people): (i) weakened emotional aversion to the prospect of harming someone due to reduced empathic concern for the victim; (ii) enhanced...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033264
PubMed Central
by Volgyi, Eszter; Carroll, Kecia N.; Hare, Marion E.; Ringwald-Smith, Karen; Piyathilake, Chandrika; Yoo, Wonsuk; Tylavsky, Frances A.
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This article is from Nutrients , volume 5 . Abstract Dietary patterns are sensitive to differences across socio-economic strata or cultural habits and may impact programing of diseases in later life. The purpose of this study was to identify distinct dietary patterns during pregnancy in the Mid-South using factor analysis. Furthermore, we aimed to analyze the differences in the food groups and in macro- and micronutrients among the different food patterns. The study was a cross-sectional...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708333
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title compound, [Zn(C8H6N5O4)2(H2O)2], the six-coordinate ZnII ion, which is located on an inversion center, has a distorted octa­hedral configuration. Each 5-carb­oxy-2-[(1H-1,2,4-triazol-1-yl)meth­yl]-1H-imidazole-4-carboxyl­ate ligand chelates to the ZnII ion through a triazole N atom and a carboxyl­ate O atom in the equatorial plane. The coordination sphere is completed by two...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238584
PubMed Central
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This article is from Central European Journal of Urology , volume 64 . Abstract We report a rare case of a patient presenting with scrotal hematoma associated with retroperitoneal hemorrhage after extracorporeal shock wave lithotripsy (ESWL). We propose a mechanism for the formation of scrotal hematoma and its importance as a sign of retroperitoneal hemorrhage.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921738
PubMed Central
by Hage, Eveline; Roo, John P; van Offenbeek, Marjolein AG; Boonstra, Albert
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This article is from BMC Health Services Research , volume 13 . Abstract Background: An ageing population is seen as a threat to the quality of life and health in rural communities, and it is often assumed that e-Health services can address this issue. As successful e-Health implementation in organizations has proven difficult, this systematic literature review considers whether this is so for rural communities. This review identifies the critical implementation factors and, following the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575225
PubMed Central
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This article is from PLoS ONE , volume 8 . Abstract This paper describes the fabrication of transparent electrodes based on grids of copper microwires using a non-photolithographic process. The process—“abrasion lithography”—takes two forms. In the first implementation (Method I), a water-soluble commodity polymer film is abraded with a sharp tool, coated with a conductive film, and developed by immersion in water. Water dissolves the polymer film and lifts off the conductive film in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866148
PubMed Central
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This article is from Colombia Médica : CM , volume 43 . Abstract Objectives:: To describe the changes that occurred in some patterns of socio-demographic variables and in living conditions among the Nasa, Guambiana and Afrocolombian populations in the northern region of the Department of Cauca, and those occurring in two residential communities, one white-mestizo and one black, in Cali during the 1993-2005 period. Methods:: This paper presents a descriptive study that analyzes several...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4001941
PubMed Central
by Kim, Jeong-Hwan; Nam, Soo-Wan; Kim, Byung-Woo; Choi, Woobong; Lee, Jong-Hwan; Kim, Wun-Jae; Choi, Yung-Hyun
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This article is from International Journal of Molecular Sciences , volume 11 . Abstract The present study was designed to investigate the question of whether or not astaxanthin improves stem cell potency via an increase in proliferation of neural progenitor cells (NPCs). Treatment with astaxanthin significantly increased proliferation and colony formation of NPCs. For identification of possible activated signaling molecules involved in active cell proliferation occurring after astaxanthin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100832
PubMed Central
by Ottosson, Sandra; Zackrisson, Bjorn; Kjellen, Elisabeth; Nilsson, Per; Laurell, Goran
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This article is from Acta Oncologica (Stockholm, Sweden) , volume 52 . Abstract Background: Weight loss is common among patients with squamous cell carcinoma of the head and neck (SCCHN) and is mainly due to tumor and treatment related factors. The aim of the present study was to evaluate weight loss in patients with SCCHN undergoing two different radiotherapy (RT) schedules. Material and methods: Nutritional data were analyzed from the ARTSCAN study, a controlled randomized prospective Swedish...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622234
PubMed Central
by Kim, Eun Sun; Chang, Yun Sil; Choi, Soo Jin; Kim, Jin Kyu; Yoo, Hey Soo; Ahn, So Yoon; Sung, Dong Kyung; Kim, Soo Yoon; Park, Ye Rim; Park, Won Soon
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This article is from Respiratory Research , volume 12 . Abstract Background: Human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuate hyperoxic neonatal lung injury primarily through anti-inflammatory effects. We hypothesized that intratracheal transplantation of human UCB-derived MSCs could attenuate Escherichia coli (E. coli)-induced acute lung injury (ALI) in mice by suppressing the inflammatory response. Methods: Eight-week-old male ICR mice were randomized to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166924
PubMed Central
by Atinga, Roger A; Mensah, Sylvester A; Asenso-Boadi, Francis; Adjei, Francis-Xavier Andoh
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This article is from BMC Health Services Research , volume 12 . Abstract Background: In 2003 Ghana introduced a social health insurance scheme which resulted in the separation of purchasing of health services by the health insurance authority on the one hand and the provision of health services by hospitals at the other side of the spectrum. This separation has a lot of implications for managing accredited hospitals. This paper examines whether decoupling purchasing and service provision...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407489
PubMed Central
by Tuteja, Amit; Siddiqui, Abu Baker; Madan, Kaushal; Goyal, Rohit; Shalimar,; Sreenivas, Vishnubhatla; Kaur, Navkiran; Panda, Subrat K.; Narayanasamy, Krishnamoorthy; Subodh, Swati; Acharya, Subrat K.
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This article is from PLoS ONE , volume 9 . Abstract Aims: The aim of this study was to investigate the genomic mutations in the circulating Hepatitis B virus strains causing infection in the Indian population. Further, we wanted to analyze the biological significance of these mutations in HBV mediated disease. Methods: 222 HBsAg positive patients were enrolled in the study. The genotype and mutation profile was determined for the infecting HBV isolate by sequencing overlapping fragments. These...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956465
This article is from BMC Pediatrics , volume 12 . Abstract Background: The new growth charts in the UK, the UK-WHO charts, comprise prescriptive data from the WHO standard between two weeks and four years of age. Little is known about the development of obesity risk in normal UK infants, who are necessarily not fed according to the WHO recommendations and do not live in constraint-free environments (the selection criteria of the WHO standard source sample), using the new charts. Here, we...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439315
PubMed Central
by Ding, Keyue; de Andrade, Mariza; Manolio, Teri A.; Crawford, Dana C.; Rasmussen-Torvik, Laura J.; Ritchie, Marylyn D.; Denny, Joshua C.; Masys, Daniel R.; Jouni, Hayan; Pachecho, Jennifer A.; Kho, Abel N.; Roden, Dan M.; Chisholm, Rex; Kullo, Iftikhar J.
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This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract To identify novel genetic loci influencing interindividual variation in red blood cell (RBC) traits in African-Americans, we conducted a genome-wide association study (GWAS) in 2315 individuals, divided into discovery (n = 1904) and replication (n = 411) cohorts. The traits included hemoglobin concentration (HGB), hematocrit (HCT), RBC count, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704235
This article is from BMC Medicine , volume 10 . Abstract Background: Failure rates in postgraduate examinations are often high and many candidates therefore retake examinations on several or even many times. Little, however, is known about how candidates perform across those multiple attempts. A key theoretical question to be resolved is whether candidates pass at a resit because they have got better, having acquired more knowledge or skills, or whether they have got lucky, chance helping them...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394208
PubMed Central
by Kaur, Manpreet; Butcher, Ray J.; Akkurt, Mehmet; Yathirajan, H. S.; Nagaraj, B.
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract The asymmetric unit of the title compound, C21H27NO, contains two mol­ecules (A and B). In mol­ecule A, the central ring of the anthrone unit adopts a shallow boat conformation and the dihedral angle between the benzene rings is 18.96 (7)°. In mol­ecule B, the central ring is close to being planar (r.m.s. deviation = 0.078 Å) and the dihedral angle between the aromatic rings is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569237
PubMed Central
by ALTOMARE, Roberta; CACCIABAUDO, Francesco; DAMIANO, Giuseppe; PALUMBO, Vincenzo Davide; GIOVIALE, Maria Concetta; BELLAVIA, Maurizio; TOMASELLO, Giovanni; LO MONTE, Attilio Ignazio
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This article is from Iranian Journal of Public Health , volume 42 . Abstract The Mediterranean tradition offers a cousine rich in colors, aromas and memories, which support the taste and the spirit of those who live in harmony with nature. Everyone is talking about the Mediterranean diet, but few are those who do it properly, thus generating a lot of confusion in the reader. And so for some it coincides with the pizza, others identified it with the noodles with meat sauce, in a mixture of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684452
PubMed Central
by Kourkouta, Lambrini; Papathanasiou, Ioanna V.
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This article is from Materia Socio-Medica , volume 26 . Abstract Good communication between nurses and patients is essential for the successful outcome of individualized nursing care of each patient. To achieve this, however, nurses must understand and help their patients, demonstrating courtesy, kindness and sincerity. Also they should devote time to the patient to communicate with the necessary confidentiality, and must not forget that this communication includes persons who surround the sick...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990376
PubMed Central
by Thijssen, Dick H. J.; Cable, N. Timothy; Green, Daniel J.
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This article is from Clinical Science (London, England : 1979) , volume 122 . Abstract Thickening of the carotid artery wall has been adopted as a surrogate marker of pre-clinical atherosclerosis, which is strongly related to increased cardiovascular risk. The cardioprotective effects of exercise training, including direct effects on vascular function and lumen dimension, have been consistently reported in asymptomatic subjects and those with cardiovascular risk factors and diseases. In the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233305
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This article is from Iranian Journal of Public Health , volume 40 . Abstract Background:: To evaluate public perceptions towards the causes of depression and schizophrenia and identifications of factors resulting stigma towards mental ill. Method:: A cross-sectional study was conducted among the inhabitants of Pulau-Pinang, Malaysia in March, 2009. A 24-item questionnaire was used to obtain respondent views. A non-probability (i.e convenient sampling method) was used to approach the potential...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481715
PubMed Central
by Lazzeroni, M; Guerrieri-Gonzaga, A; Botteri, E; Leonardi, M C; Rotmensz, N; Serrano, D; Varricchio, C; Disalvatore, D; Castillo, A Del; Bassi, F; Pagani, G; DeCensi, A; Viale, G; Bonanni, B; Pruneri, G
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This article is from British Journal of Cancer , volume 108 . Abstract Background:: The post-surgical management of ductal intraepithelial neoplasia (DIN) of the breast is still a dilemma. Ki-67 labelling index (LI) has been proposed as an independent predictive and prognostic factor in early breast cancer. Methods:: The prognostic and predictive roles of Ki-67 LI were evaluated with a multivariable Cox regression model in a cohort of 1171 consecutive patients operated for DIN in a single...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668474
PubMed Central
by Houshdar Tehrani, Mohammad Hassan; Fakhrehoseini, Elham; Kamali Nejad, Mohammad; Mehregan, Hadi; Hakemi-Vala, Mojdeh
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This article is from Iranian Journal of Pharmaceutical Research : IJPR , volume 11 . Abstract The edible mushrooms (basidomycetes) have high nutritional value, promote the immune system, and as a source of natural antimicrobial substances have been used to cure bacterial infections since ancient times.Various kinds of proteins with several biological activities are produced by mushrooms. In this research, in order to evaluate antibacterial activity of edible mushrooms, we isolated proteins of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813085
PubMed Central
by Lindner, Nicole M.; Graser, Alexander; Nosek, Brian A.
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This article is from PLoS ONE , volume 9 . Abstract Participants completed a questionnaire priming them to perceive themselves as either objective or biased, either before or after evaluating a young or old job applicant for a position linked to youthful stereotypes. Participants agreed that they were objective and tended to disagree that they were biased. Extending past research, both the objective and bias priming conditions led to an increase in age discrimination compared to the control...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897397
PubMed Central
by Campion, Alicia; Casey, Pat G; Field, Des; Cotter, Paul D; Hill, Colin; Ross, R Paul
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This article is from BMC Microbiology , volume 13 . Abstract Background: Lantibiotics are post-translationally modified antimicrobial peptides, of which nisin A is the most extensively studied example. Bioengineering of nisin A has resulted in the generation of derivatives with increased in vitro potency against Gram-positive bacteria. Of these, nisin V (containing a Met21Val change) is noteworthy by virtue of exhibiting enhanced antimicrobial efficacy against a wide range of clinical and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616995
PubMed Central
by Dreos, Rene; Ambrosini, Giovanna; Cavin Perier, Rouayda; Bucher, Philipp
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This article is from Nucleic Acids Research , volume 41 . Abstract The Eukaryotic Promoter Database (EPD), available online at http://epd.vital-it.ch, is a collection of experimentally defined eukaryotic POL II promoters which has been maintained for more than 25 years. A promoter is represented by a single position in the genome, typically the major transcription start site (TSS). EPD primarily serves biologists interested in analysing the motif content, chromatin structure or DNA methylation...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531148
PubMed Central
by Schopf, Veronika; Fischmeister, Florian Ph. S.; Windischberger, Christian; Gerstl, Florian; Wolzt, Michael; Karlsson, Karl AE.; Moser, Ewald
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This article is from Frontiers in Human Neuroscience , volume 7 . Abstract This study aimed to directly assess the effect of changes in blood glucose levels on the psychological processing of emotionally charged material. We used functional magnetic resonance imaging (fMRI) to evaluate the effect of blood glucose levels on three categories of visually presented emotional stimuli. Seventeen healthy young subjects participated in this study (eight females; nine males; body weight, 69.3 ± 14.9...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659280
PubMed Central
by Neuba, Adam; Florke, Ulrich; Henkel, Gerald
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 68 . Abstract The mol­ecular structure of the title compound, [Cu(C11H16N3O3S)2], shows the CuII atom with a distorted square-planar coordination geometry from the N2O2 donor set of the two chelating 2-{[bis­(dimethyl­amino)­methyl­idene]amino}­benzene­sulfonate ligands. The CuII atom lies 0.065 (1) Å above the N2O2 plane and the Cu—O [2 × 1.945 (2) Å] and Cu—N bond lengths...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588740
PubMed Central
by Byrd, Allyson L; Perez-Rogers, Joseph F; Manimaran, Solaiappan; Castro-Nallar, Eduardo; Toma, Ian; McCaffrey, Tim; Siegel, Marc; Benson, Gary; Crandall, Keith A; Johnson, William Evan
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This article is from BMC Bioinformatics , volume 15 . Abstract Background: The use of sequencing technologies to investigate the microbiome of a sample can positively impact patient healthcare by providing therapeutic targets for personalized disease treatment. However, these samples contain genomic sequences from various sources that complicate the identification of pathogens. Results: Here we present Clinical PathoScope, a pipeline to rapidly and accurately remove host contamination, isolate...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131054
PubMed Central
by Cleutjens, Fiona A H M; Wouters, Emiel F M; Dijkstra, Jeanette B; Spruit, Martijn A; Franssen, Frits M E; Vanfleteren, Lowie E G W; Ponds, Rudolf W H M; Janssen, Daisy J A
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This article is from BMJ Open , volume 4 . Abstract Introduction: Intact cognitive functioning is necessary for patients with chronic obstructive pulmonary disease (COPD) to understand the value of healthy lifestyle guidelines, to make informed decisions and subsequently act on it. Nevertheless, brain abnormalities and cognitive impairment have been found in patients with COPD. To date, it remains unknown which cognitive domains are affected and what the possible consequences are of cognitive...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948451
PubMed Central
by Peck, Hannah L.; Pringle, Henrietta E.; Marshall, Harry H.; Owens, Ian P.F.; Lord, Alexa M.
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This article is from Behavioral Ecology , volume 25 . Abstract Invasive rose-ringed parakeets caused behavioral changes in native garden birds that reduced their feeding rates. Understanding how invasive species impact native species can be complex, especially in urban environments where many other factors are also at play. We therefore used an experiment to disentangle these factors and demonstrate that parakeets are more disruptive than a dominant native competitor.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014307
PubMed Central
by Tuna, Elif Bahar; Dundar, Aysun; Cankaya, Abdulkadir Burak; Gencay, Koray
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This article is from The Open Dentistry Journal , volume 6 . Abstract Condylar fractures in children are especially important because of the risk of a mandibular growth-center being affected in the condylar head, which can lead to growth retardation and facial asymmetry. The purpose of this article is to follow up the two and half year clinical and radiological evaluation of the conservative treatment of a 10 year-old patient, who had a unilateral green-stick type fracture. The patient...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263469
PubMed Central
by A, Taccaliti; F, Silvetti; G, Palmonella; M, Boscaro
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This article is from Current Genomics , volume 12 . Abstract Medullary thyroid carcinoma (MTC) is a rare calcitonin producing neuroendocrine tumour that originates from the parafollicular C-cells of the thyroid gland. The RET proto-oncogene encodes the RET receptor tyrosine kinase, with consequently essential roles in cell survival, differentiation and proliferation. Somatic or germline mutations of the RET gene play an important role in this neoplasm in development of sporadic and familial...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271314
PubMed Central
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This article is from Journal of Cardiovascular Magnetic Resonance , volume 16 . Abstract None
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042342
This article is from European Journal of Dentistry , volume 7 . Abstract Objectives:: Various coronally repositioned flap (CRF) techniques have been proposed for coverage of gingival recession defects. Although CRF has several modifications all of them needs vertical or oblique external releasing incisions for treatment of localized gingival recession defects. The aim of present article was to evaluate the effectiveness of a modification of the new CRF procedure without any releasing incision...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053628
PubMed Central
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This article is from Oncoimmunology , volume 1 . Abstract Successful cancer immunotherapy is thought to require de novo priming of tumor specific CD8+ T cells in lymphatic organs. Contrasting these beliefs, cancer therapy based on interleukin-10 (IL-10) results in tumor rejection without a requirement for T-cell trafficking from lymphatic organs. Rather, IL-10 directly activates autochthonous, tumor-resident CD8+ T cells.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525629
PubMed Central
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This article is from BMC Public Health , volume 14 . Abstract Background: Premarital medical examination (PME) compliance rate has dropped drastically since it became voluntary in China in 2003. This study aimed to establish a prediction model to be a theoretic framework for analyzing factors affecting PME compliance in Zhejiang province, China. Methods: A culturally-tailored health behavioral model combining the Health Behavioral Model (HBM) and the Theory of Reasoned Action (TRA) was...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094453
PubMed Central
by Diler, Songul Budak; Ergene, Serap
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This article is from Genetics and Molecular Biology , volume 33 . Abstract The micronucleus (MN) assay on exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. To determine the genotoxic effects of calcite dust that forms during processing, MN assay was carried out in exfoliated buccal cells of 50 (25 smokers and 25 non-smokers) calcite factory workers and 50 (25 smokers and 25 non-smokers) age- and sex-matched control subjects. Frequencies...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3036877
PubMed Central
by Worku, Abebaw Gebeyehu; Yalew, Alemayehu Worku; Afework, Mesganaw Fantahun
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This article is from BMC International Health and Human Rights , volume 13 . Abstract Background: The evaluation of all potential sources of low skilled maternal care utilization is crucial for Ethiopia. Previous studies have largely disregarded the contribution of different levels. This study was planned to assess the effect of individual, communal, and health facility characteristics in the utilization of antenatal, delivery, and postnatal care by a skilled provider. Methods: A linked...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639034
PubMed Central
by Deramaudt, Therese B.; Dujardin, Denis; Noulet, Fanny; Martin, Sophie; Vauchelles, Romain; Takeda, Ken; Ronde, Philippe
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This article is from PLoS ONE , volume 9 . Abstract Focal adhesion kinase (FAK) plays an important role in signal transduction pathways initiated at sites of integrin-mediated cell adhesion to the extracellular matrix. Thus, FAK is involved in many aspects of the metastatic process including adhesion, migration and invasion. Recently, several small molecule inhibitors which target FAK catalytic activity have been developed by pharmaceutical companies. The current study was aimed at addressing...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958421
PubMed Central
by Kikuchi, Y; Kume, A; Urabe, M; Mizukami, H; Suzuki, T; Ozaki, K; Nagai, T; Ozawa, K
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This article is from Journal of Stem Cells & Regenerative Medicine , volume 7 . Abstract Although mesenchymal stem cells (MSCs) play pivotal supportive roles in hematopoiesis, how they interact with hematopoietic stem cells (HSCs) is not well understood. We investigated the interaction between HSCs and surrogate MSCs (C3H10T1/2 stromal cells), focusing on the molecular events induced by cell contact of these bipartite populations. C3H10T1/2 is a mesenchymal stromal cell line that can be...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908275
PubMed Central
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This article is from Pediatric Gastroenterology, Hepatology & Nutrition , volume 16 . Abstract Purpose: The aim of this study was to compare the efficacy and safety of band ligation and injection sclerotherapy in the endoscopic treatment of children with variceal bleeding. Methods: The study population included 55 children, all of whom were treated at the time of endoscopic diagnosis of esophageal varices at Asan Medical Center, Seoul, Korea, between January 1994 and January 2011. The...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915733
PubMed Central
by Spolverato, Gaya; Pucciarelli, Salvatore; Bertorelle, Roberta; De Rossi, Anita; Nitti, Donato
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This article is from Cancers , volume 3 . Abstract Locally advanced rectal cancer is currently treated with pre-operative radiochemotherapy (pRCT), but the response is not uniform. Identification of patients with higher likelihood of responding to pRCT is clinically relevant, as patients with resistant tumors could be spared exposure to radiation or DNA-damaging drugs that are associated with adverse side effects. To highlight predictive biomarkers of response to pRCT, a systematic search of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757411
PubMed Central
by Hudson, Robert S; Yi, Ming; Volfovsky, Natalia; Prueitt, Robyn L; Esposito, Dominic; Volinia, Stefano; Liu, Chang-Gong; Schetter, Aaron J; Van Roosbroeck, Katrien; Stephens, Robert M; Calin, George A; Croce, Carlo M; Ambs, Stefan
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This article is from Molecular Cancer , volume 12 . Abstract Background: Ultraconserved regions (UCR) are genomic segments of more than 200 base pairs that are evolutionarily conserved among mammalian species. They are thought to have functions as transcriptional enhancers and regulators of alternative splicing. Recently, it was shown that numerous RNAs are transcribed from these regions. These UCR-encoded transcripts (ucRNAs) were found to be expressed in a tissue- and disease-specific manner...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626580
PubMed Central
by Donga, Esther; van Dijk, Marieke; van Dijk, J. Gert; Biermasz, Nienke R.; Lammers, Gert-Jan; van Kralingen, Klaas; Hoogma, Roel P.L.M.; Corssmit, Eleonora P.M.; Romijn, Johannes A.
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This article is from Diabetes Care , volume 33 . Abstract OBJECTIVE: Sleep restriction results in decreased insulin sensitivity and glucose tolerance in healthy subjects. We hypothesized that sleep duration is also a determinant of insulin sensitivity in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied seven patients (three men, four women) with type 1 diabetes: mean age 44 ± 7 years, BMI 23.5 ± 0.9 kg/m2, and A1C 7.6 ± 0.3%. They were studied once after a night of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890361
PubMed Central
by Bauer, Ulrike; Grafe, T. Ulmar; Federle, Walter
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This article is from Journal of Experimental Botany , volume 62 . Abstract Nepenthes pitchers are specialized leaves that function as insect traps. Several pitcher components may contribute to trapping, including the pitcher fluid, slippery wax crystals and downward-pointing epidermal cells on the inner pitcher wall, and the wetness-dependent pitcher rim (peristome), but the relative importance of these traits is unclear. Mechanisms of prey capture and retention in the field were investigated...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130184
PubMed Central
by Galderisi, Maurizio; Nistri, Stefano; Mondillo, Sergio; Losi, Maria-Angela; Innelli, Pasquale; Mele , Donato; Muraru, Denisa; D'Andrea, Antonello; Ballo, Piercarlo; Sgalambro, Aurelio; Esposito, Roberta; Marti, Giuliano; Santoro, Alessandro; Agricola, Eustachio; Badano, Luigi P; Marchioli, Roberto; Filardi, Pasquale Perrone; Mercuro, Giuseppe; Marino, Paolo Nicola
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This article is from Cardiovascular Ultrasound , volume 9 . Abstract When applying echo-Doppler imaging for either clinical or research purposes it is very important to select the most adequate modality/technology and choose the most reliable and reproducible measurements. Quality control is a mainstay to reduce variability among institutions and operators and must be obtained by using appropriate procedures for data acquisition, storage and interpretation of echo-Doppler data. This goal can be...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3200147
PubMed Central
by Moore, Lynette M.; Holmes, Kristen M.; Fuller, Gregory N.; Zhang, Wei
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This article is from Chinese Journal of Cancer , volume 30 . Abstract The aggressive and invasive nature of brain tumors has hampered progress in the design and implementation of efficacious therapies. The recent success of targeted therapies in other tumor types makes this an attractive area for research yet complicating matters is the ability of brain tumors to circumvent the targeted pathways to develop drug resistance. Effective therapies will likely need to target more than one signaling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013312
PubMed Central
by Pineda-Munoz, Silvia; Alroy, John
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This article is from Proceedings of the Royal Society B: Biological Sciences , volume 281 . Abstract Understanding the feeding behaviour of the species that make up any ecosystem is essential for designing further research. Mammals have been studied intensively, but the criteria used for classifying their diets are far from being standardized. We built a database summarizing the dietary preferences of terrestrial mammals using published data regarding their stomach contents. We performed...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100522