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Jun 23, 2022 Eklund, Britt-Marie; Nilsson, Siv; Hedman, Linnea; Lindberg, Inger
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This article is from Tobacco Induced Diseases , volume 10 . Abstract Background: Chronic Obstructive Pulmonary Disease (COPD) is currently one of the most widespread chronic lung diseases and a growing cause of suffering and mortality worldwide. It is predicted to become the third leading cause of death in the near future. Smoking is the most important risk factor, and about 50% of smokers develop COPD. Smoking cessation is the most important way to improve prognosis. The aim of the study was...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488476
This article is from Asian-Australasian Journal of Animal Sciences , volume 27 . Abstract Different herbs and spices have been used as feed additives for various purposes in poultry production. This study was conducted to assess the effect of feed supplemented with black pepper (Piper nigrum), turmeric powder (Curcuma longa), coriander seeds (Coriandrum sativum) and their combinations on the performance of broilers. A total of 210 (Cobb) one-d-old chicks were divided into seven groups of 30...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4093167
PubMed Central
Mar 26, 2022 Knoll, Alexander; Schropfer, Susan; Puchta, Holger
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This article is from Frontiers in Plant Science , volume 5 . Abstract The RTR complex consisting of a RecQ helicase, a type IA topoisomerase and the structural protein RMI1 is involved in the processing of DNA recombination intermediates in all eukaryotes. In Arabidopsis thaliana the complex partners RECQ4A, topoisomerase 3α and RMI1 have been shown to be involved in DNA repair and in the suppression of homologous recombination in somatic cells. Interestingly, mutants of AtTOP3A and AtRMI1 are...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921566
PubMed Central
Nov 1, 2021 ALTOMARE, Roberta; CACCIABAUDO, Francesco; DAMIANO, Giuseppe; PALUMBO, Vincenzo Davide; GIOVIALE, Maria Concetta; BELLAVIA, Maurizio; TOMASELLO, Giovanni; LO MONTE, Attilio Ignazio
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This article is from Iranian Journal of Public Health , volume 42 . Abstract The Mediterranean tradition offers a cousine rich in colors, aromas and memories, which support the taste and the spirit of those who live in harmony with nature. Everyone is talking about the Mediterranean diet, but few are those who do it properly, thus generating a lot of confusion in the reader. And so for some it coincides with the pizza, others identified it with the noodles with meat sauce, in a mixture of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684452
PubMed Central
Feb 28, 2021 Maroja, Luana S; McKenzie, Zachary M; Hart, Elizabeth; Jing, Joy; Larson, Erica L; Richardson, David P
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This article is from BMC Evolutionary Biology , volume 14 . Abstract Background: Pre-zygotic barriers often involve some form of sexual selection, usually interpreted as female choice, as females are typically the choosier sex. However, males typically show some mate preferences, which are increasingly reported. Here we document previously uncharacterized male courtship behavior (effort and song) and cuticular hydrocarbon (CHC) profiles in the hybridizing crickets Gryllus firmus and G....
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4137559
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This article is from PeerJ , volume 2 . Abstract Understanding female mate preference is important for determining the strength and direction of sexual trait evolution. The sound pressure level (SPL) acoustic signalers use is often an important predictor of mating success because higher sound pressure levels are detectable at greater distances. If females are more attracted to signals produced at higher sound pressure levels, then the potential fitness impacts of signalling at higher sound...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060022
PubMed Central
Jan 26, 2021 Yoon, Gyeong Mee; Kieber, Joseph J.
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This article is from AoB Plants , volume 5 . Abstract This review summarizes and discusses the role of ACC synthase in plants. The classic role of ACC synthase is to act as the key enzyme in the biosynthetic pathway for the plant hormone ethylene. Several recent papers have converged on the notion that ACC, the immediate product of ACC synthase, acts as a novel signaling molecule in plants independent of its conversion to ethylene. The evidence for this hypothesis from these papers and...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104647
PubMed Central
Sep 22, 2020 Lyon, Louisa; Burnet, Philip WJ; Kew, James NC; Corti, Corrado; Rawlins, J Nicholas P; Lane, Tracy; De Filippis, Bianca; Harrison, Paul J; Bannerman, David M
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This article is from Neuropsychopharmacology , volume 36 . Abstract Group II metabotropic glutamate receptors (mGluR2 and mGluR3, encoded by GRM2 and GRM3) are implicated in hippocampal function and cognition, and in the pathophysiology and treatment of schizophrenia and other psychiatric disorders. However, pharmacological and behavioral studies with group II mGluR agonists and antagonists have produced complex results. Here, we studied hippocampus-dependent memory in GRM2/3 double knockout...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230485
PubMed Central
Jul 7, 2020 Belouzard, Sandrine; Millet, Jean K.; Licitra, Beth N.; Whittaker, Gary R.
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This article is from Viruses , volume 4 . Abstract Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tropism and pathogenesis. It is classified as a class I fusion protein, and is responsible for binding to the receptor on the host cell as well as...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397359
PubMed Central
Mar 24, 2020 Pabinger, Stephan; Dander, Andreas; Fischer, Maria; Snajder, Rene; Sperk, Michael; Efremova, Mirjana; Krabichler, Birgit; Speicher, Michael R.; Zschocke, Johannes; Trajanoski, Zlatko
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This article is from Briefings in Bioinformatics , volume 15 . Abstract Recent advances in genome sequencing technologies provide unprecedented opportunities to characterize individual genomic landscapes and identify mutations relevant for diagnosis and therapy. Specifically, whole-exome sequencing using next-generation sequencing (NGS) technologies is gaining popularity in the human genetics community due to the moderate costs, manageable data amounts and straightforward interpretation of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956068
PubMed Central
Jun 26, 2019 Dreon, Marcos S.; Fernandez, Patricia E.; Gimeno, Eduardo J.; Heras, Horacio
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This article is from PLoS Neglected Tropical Diseases , volume 8 . Abstract Background: The spread of the invasive snail Pomacea canaliculata is expanding the rat lungworm disease beyond its native range. Their toxic eggs have virtually no predators and unusual defenses including a neurotoxic lectin and a proteinase inhibitor, presumably advertised by a warning coloration. We explored the effect of egg perivitellin fluid (PVF) ingestion on the rat small intestine morphology and physiology....
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063725
PubMed Central
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This article is from Frontiers in Psychology , volume 5 . Abstract There is a gap between proposed theoretical attachment theory frameworks, measures of attachment in the assessment phase and their relationship with changes in outcome after a psychodynamic oriented psychotherapy. Based on a clinical case study of a young woman with Panic Attack Disorder, this paper examined psychotherapy outcome findings comparing initial and post-treatment assessments, according to the mental functioning in S...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138773
PubMed Central
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 69 . Abstract Practical chemistry courses at universities very frequently propose the synthesis and characterization of [Co(CO3)(NH3)4]NO3, but this goal is never achieved since students only obtain the hemihydrated form. The anhydrous form can be prepared, however, and its structure is presented here. Similar to the hemihydrate form, the anhydrous phase contains the CoIII ion in an octahedral O2N4...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772400
This article is from Social History of Medicine , volume 27 . Abstract Public fears of widespread venereal disease led in 1913 to the appointment of The Royal Commission on Venereal Diseases (RCVD). In 1916 its Final Report offered only a single cautious and somewhat imprecise summary statement about the likely prevalence of venereal diseases in England and Wales. Although the significance of contemporary attitudes to venereal disease has attracted a good deal of historiographic attention, no...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109696
PubMed Central
Jul 28, 2017 Galati, Giovanni; De Vincentis, Antonio; Vespasiani-Gentilucci, Umberto; Gallo, Paolo; Vincenti, Donatella; Solmone, Maria Carmela; Dell'Unto, Chiara; Picardi, Antonio
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This article is from BMC Gastroenterology , volume 14 . Abstract Background: Some reports have documented the coexistence of Hepatitis B surfage Antigen (HBsAg) and anti-HBsAg antibodies (HBsAb) in patients with chronic hepatitis B (CHB), often in the absence of amino acid substitutions in the HBsAg sequences of the Hepatitis B Virus (HBV) genome able to explain an immunological escape variant.HBV genome has a very compact coding organization, with four partially overlapping open reading frames...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031327
PubMed Central
Nov 1, 2016 Joksic, Gordana; Spasojevic-Tisma, Vera; Antic, Ruza; Nilsson, Robert; Rutqvist, Lars E
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This article is from Harm Reduction Journal , volume 8 . Abstract Background: Epidemiological studies suggest that smokeless tobacco in the form of Swedish snus has been used by many smokers in Scandinavia to quit smoking, but the efficacy of snus has so far not been evaluated in controlled clinical trials. Methods: We conducted a randomized, double-blind, placebo-controlled, clinical trial aimed at assessing the efficacy of snus to help adult cigarette smokers in Serbia to substantially...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186733
PubMed Central
Jul 6, 2016 Ferguson, Lydia; Agoulnik, Alexander I.
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This article is from Frontiers in Endocrinology , volume 4 . Abstract The failure of testicular descent or cryptorchidism is the most common defect in newborn boys. The descent of the testes during development is controlled by insulin-like 3 peptide and steroid hormones produced in testicular Leydig cells, as well as by various genetic and developmental factors. While in some cases the association with genetic abnormalities and environmental causes has been shown, the etiology of cryptorchidism...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602796
PubMed Central
Jun 22, 2016 Tsang, Siu Wai; Zhang, Hongjie; Lin, Chengyuan; Xiao, Haitao; Wong, Michael; Shang, Hongcai; Yang, Zhi-Jun; Lu, Aiping; Yung, Ken Kin-Lam; Bian, Zhaoxiang
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This article is from PLoS ONE , volume 8 . Abstract Pancreatic fibrosis, a prominent histopathological feature of chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma, is essentially a dynamic process that leads to irreversible scarring of parenchymal tissues of the pancreas. Though the exact mechanisms of its initiation and development are poorly understood, recent studies suggested that the activation of pancreatic stellate cells (PSCs) plays a critical role in eliciting such active...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849497
PubMed Central
Dec 4, 2015 Bauer, Michael; Fetherstonhaugh, Deirdre; Tarzia, Laura; Nay, Rhonda; Beattie, Elizabeth
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This article is from BMC Geriatrics , volume 14 . Abstract Background: Sexuality is a key component of quality of life and well-being and a need to express one’s sexuality continues into old age. Staff and families in residential aged care facilities often find expressions of sexuality by residents, particularly those living with dementia, challenging and facilities often struggle to address individuals’ needs in this area. This paper describes the development of an assessment tool which...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085662
PubMed Central
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This article is from BMC Health Services Research , volume 11 . Abstract Health planners and managers make decisions based on their appreciation of causality. Social audits question the assumptions behind this and try to improve quality of available evidence. The method has its origin in the follow-up of Bhopal survivors in the 1980s, where “cluster cohorts” tracked health events over time. In social audit, a representative panel of sentinel sites are the framework to follow the impact of...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397387
PubMed Central
Jun 23, 2015 Cheng, Yi-Shing Lisa; Rees, Terry; Wright, John
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This article is from Clinical and Translational Medicine , volume 3 . Abstract Using saliva for disease diagnostics and health surveillance is a promising approach as collecting saliva is relatively easy and non-invasive. Over the past two decades, using salivary biomarkers specifically for early cancer detection has attracted much research interest, especially for cancers occurring in the oral cavity and oropharynx, for which the five-year survival rate (62%) is still one of the lowest among...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945802
PubMed Central
Jun 23, 2015 Jurel, Sunit Kumar; Gupta, Durga Shanker; Singh, Raghuwar D.; Singh, Mrinalini; Srivastava, Shilpi
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This article is from Indian Journal of Human Genetics , volume 20 . Abstract Oral cancers have been one of the leading causes of deaths particularly in the developing countries. Prime reason for this high mortality and morbidity is attributed to the delay in diagnosis and prompt treatment. Relentless research in the field of oncology has led to the advent of novel procedures for the early detection of oral cancers. Molecular biology is highly promising in this regard. It is a procedure that...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065477
PubMed Central
May 2, 2015 Johnston, Rowena; Barre-Sinoussi, Francoise
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This article is from Journal of the International AIDS Society , volume 15 . Abstract Background: Antiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs. Discussion: Most efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients, with the notable exception of a stem cell transplant...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334674
PubMed Central
Dec 14, 2014 Pereira, Maite; Vieira, Neiva de Souza; Brandao, Eduardo da Rosa; Ruaro, Joao Afonso; Grignet, Rodrigo Juliano; Frez, Andersom Ricardo
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This article is from Acta Ortopedica Brasileira , volume 20 . Abstract The purpose of this study was to evaluate the existence of differences in the rehabilitation of patients after ACL reconstruction using bone-patellar tendon-bone graft and the four-strand semitendinosus and gracilis tendon grafts, through a literature revision. The researched databases were MEDLINE, EMBASE, LILACS, COCHRANE and PEDro. The inclusion criteria were published studies with methodology draw from randomized...
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Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861958
PubMed Central
- Varma, Tarun; Saini, Ashish; Panchani, Roopal; Gupta, Nitin R.
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This article is from Indian Journal of Endocrinology and Metabolism , volume 17 . Abstract Aminoglycoside (AMG)-induced renal toxicity is well-known and may manifest with non-oliguric renal failure or renal tubular dysfunction like Fanconi-like syndrome, Barter syndrome-like syndrome or distal renal tubular acidosis (RTA). These phenomena have been described with Gentamycin and Amikacin though rarely with Kanamycin. We present two cases of pulmonary tuberculosis that were treated with Kanamycin...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3830306
PubMed Central
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This article is from Tropical Parasitology , volume 4 . Abstract Introduction:: Schistosoma haematobium infection afflicts about 150 million people in 53 countries in Africa and the Middle East. In many endemic areas, S. haematobium is sympatric with Schistosoma bovis, Schistosoma mattheei, Schistosoma curassoni, Schistosoma intercalatum and Schistosoma magrebowiei, its closely related species. In addition, they also develop in the same intermediate snail hosts. Since these schistosome species...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992801
PubMed Central
- Maroufi, Maryam; Javadi, Marzieh; yaghoubi, Maryam; Karimi, Saied
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This article is from Iranian Journal of Nursing and Midwifery Research , volume 17 . Abstract Context:: Medical waste (MW) is all waste materials generated at health care facilities. MW naturally is hazardous for environment and subsequently for human. Waste minimization (WM) is the latest alternative for risk reduction. All hospital staff generally and nurses specially can play an active role through education and the implementation of measures to reduce medical wastage and their environmental...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733291
PubMed Central
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This article is from Yeast (Chichester, England) , volume 17 . Abstract The general theme of the meeting was the application of mass spectrometry to pharmaceutical and biotechnological research. The majority of the oral presentations and posters were concerned with the development and application of all mass spectrometric techniques related to proteomics.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448382
PubMed Central
- Biscetti, Federico; Straface, Giuseppe; De Cristofaro, Raimondo; Lancellotti, Stefano; Rizzo, Paola; Arena, Vincenzo; Stigliano, Egidio; Pecorini, Giovanni; Egashira, Kensuke; De Angelis, Giulia; Ghirlanda, Giovanni; Flex, Andrea
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This article is from Diabetes , volume 59 . Abstract OBJECTIVE: High-mobility group box-1 (HMGB1) protein is a nuclear DNA-binding protein released from necrotic cells, inducing inflammatory responses and promoting tissue repair and angiogenesis. Diabetic human and mouse tissues contain lower levels of HMGB1 than their normoglycemic counterparts. Deficient angiogenesis after ischemia contributes to worse outcomes of peripheral arterial disease in patients with diabetes. To test the hypothesis...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874711
This article is from Yeast (Chichester, England) , volume 17 . Abstract The rapidly accumulating genome sequence data from the plant Arabidopsis thaliana allows more detailed analysis of genome content and organisation than ever bafore possible in plants. The genome shows a surprisingly high level of genetic redundancy, with as many as 75% of gene products showing signficant homology to another protien of A. thaliana. Many duplicated genes occur in arrays of conserved order and indicate that A....
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447036
PubMed Central
- Nam, Soohyun; Chesla, Catherine; Stotts, Nancy A.; Kroon, Lisa; Janson, Susan L.
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This article is from Diabetes Care , volume 33 . Abstract OBJECTIVE: To describe the predictive relationships of selected sociodemographic, biomedical, and psychosocial variables to reluctance to use insulin among patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A total of 178 patients with type 2 diabetes participated in this cross-sectional, observational study. Data were obtained by patient interview using validated measures of diabetes attitude, knowledge, self-efficacy, care...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909055
PubMed Central
- Lawrenz, Morgan; Wereszczynski, Jeff; Amaro, Rommie; Walker, Ross; Roitberg, Adrian; McCammon, J Andrew
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This article is from Proteins , volume 78 . Abstract The highly pathogenic influenza strains H5N1 and H1N1 are currently treated with inhibitors of the viral surface protein neuraminidase (N1). Crystal structures of N1 indicate a conserved, high affinity calcium binding site located near the active site. The specific role of this calcium in the enzyme mechanism is unknown, though it has been shown to be important for enzymatic activity and thermostability. We report molecular dynamics (MD)...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902668
PubMed Central
- Weppner, William G.; Ralston, James D.; Koepsell, Thomas D.; Grothaus, Lou C.; Reid, Robert J.; Jordan, Luesa; Larson, Eric B.
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This article is from Diabetes Care , volume 33 . Abstract OBJECTIVE: Evaluate use of a web-based shared medical record (SMR) between older patients with diabetes and providers. RESEARCH DESIGN AND METHODS: This was a retrospective cohort study. Health records and SMR use patterns of 6,185 enrollees aged ≥65 years with diabetes were analyzed from implementation of a SMR in August 2003 through December 2007. We analyzed baseline predictors of age, sex, distance from clinic, socioeconomic...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963486
PubMed Central
- Moon, Hyun-Seuk; Chamberland, John P.; Diakopoulos, Kalliope N.; Fiorenza, Christina G.; Ziemke, Florencia; Schneider, Benjamin; Mantzoros, Christos S.
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This article is from Diabetes Care , volume 34 . Abstract OBJECTIVE: Amylin interacts with leptin to alter metabolism. We evaluated, for the first time, amylin- and/or leptin-activated signaling pathways in human peripheral tissues (hPTs). RESEARCH DESIGN AND METHODS: Leptin and amylin signaling studies were performed in vitro in human primary adipocytes (hPAs) and human peripheral blood mononuclear cells (hPBMCs) and ex vivo in human adipose tissue (hAT) from male versus female subjects, obese...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005478
PubMed Central
- Rodrigues, Ticiana C.; Maahs, David M.; Johnson, Richard J.; Jalal, Diana I.; Kinney, Gregory L.; Rivard, Christopher; Rewers, Marian; Snell-Bergeon, Janet K.
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This article is from Diabetes Care , volume 33 . Abstract OBJECTIVE: To examine uric acid (UA) as a possible predictor of the progression of coronary artery calcification (CAC) using data from the prospective Coronary Artery Calcification in Type 1 Diabetes (CACTI) Study. RESEARCH DESIGN AND METHODS: CAC was measured by electron beam tomography at the baseline and at a follow-up 6.0 ± 0.5 years later. The study population included 443 participants with type 1 diabetes and 526 control subjects...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963516
PubMed Central
- Hosseininaveh, Vahid; Bandani, Alireza; Hosseininaveh, Fatemeh
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This article is from Journal of Insect Science , volume 9 . Abstract The Sunn pest, Eurygaster integriceps Puton (Heteroptera: Scutelleridae), is one of the most important pests of wheat and causes considerable damage to this valuable crop annually. Digestive proteinase activity of adult insects was investigated using general and specific substrates and inhibitors. Proteolytic activity was low when the common conventional substrates, azoalbumin, azocasein and hemoglobin were used to assay...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3011966
PubMed Central
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This article is from Diabetes , volume 60 . Abstract OBJECTIVE: Polymorphic INS-VNTR plays an important role in regulating insulin transcript expression in the human thymus that leads to either insulin autoimmunity or tolerance. The molecular mechanisms underlying the INS-VNTR haplotype-dependent insulin expression are still unclear. In this study, we determined the mechanistic components underlying the differential insulin gene expression in human thymic epithelial cells, which should have...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012191
PubMed Central
- Gonzalez-Perez, Miguel A.; Newton, Craig; Sosa, Pedro A.; Rivero, Elizabeth; Gonzalez-Gonzalez, Edna A.
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This article is from Genetics and Molecular Biology , volume 32 . Abstract Six novel polymorphic microsatellite markers were isolated from enriched libraries in Myrica faya Ait., recently renamed Morella faya, (fayatree, firetree, or firebush) in order to examine the genetic diversity in natural populations. Also, test cross-specific amplification and genetic diversity in Myrica rivas-martinezii, which is endemic on the Canary islands. Microsatellite loci were screened in 225 individuals of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032956
PubMed Central
- Vacher, Helene; Yang, Jae-Won; Cerda, Oscar; Autillo-Touati, Amapola; Dargent, Benedicte; Trimmer, James S.
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This article is from The Journal of Cell Biology , volume 192 . Abstract Phosphorylation of Kvβ2 releases Kv1 channels from microtubules to control their specific distribution at the axonal membrane.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051814
PubMed Central
- Lamont, F R; Tomlinson, D C; Cooper, P A; Shnyder, S D; Chester, J D; Knowles, M A
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This article is from British Journal of Cancer , volume 104 . Abstract Background:: Activating mutations of FGFR3 are frequently identified in superficial urothelial carcinoma (UC) and increased expression of FGFR1 and FGFR3 are common in both superficial and invasive UC. Methods:: The effects of inhibition of receptor activity by three small molecule inhibitors (PD173074, TKI-258 and SU5402) were investigated in a panel of bladder tumour cell lines with known FGFR expression levels and FGFR3...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039817
This article is from Beilstein Journal of Nanotechnology , volume 2 . Abstract The ordering kinetics in free and supported L10 nanoparticles was studied by means of lattice-based kinetic Monte-Carlo simulations. Starting from a fully disordered particle of Wulff shape, the simulations show that the nucleation of ordered domains is starting quickly on various (100) facets but is retarded in the particle volume due to the lack of vacancies compared with a thin film geometry. If a substrate is...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045943
PubMed Central
- Ferrara, Assiamira; Lewis, James D.; Quesenberry, Charles P.; Peng, Tiffany; Strom, Brian L.; Van Den Eeden, Stephen K.; Ehrlich, Samantha F.; Habel, Laurel A.
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This article is from Diabetes Care , volume 34 . Abstract OBJECTIVE: To explore whether treatment with pioglitazone was associated with risk of incident cancer at the 10 most common sites (prostate, female breast, lung/bronchus, endometrial, colon, non-Hodgkin lymphoma [NHL], pancreas, kidney/renal pelvis, rectal, and melanoma). RESEARCH DESIGN AND METHODS: A cohort study of 252,467 patients aged ≥40 years from the Kaiser Permanente Northern California Diabetes Registry was conducted. All...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064052
PubMed Central
- Oh, Ju-Young; Yang, Dong-Il; Chon, Ki-Hwan
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This article is from Healthcare Informatics Research , volume 16 . Abstract Objectives: The transmission of medical information is currently a daily routine. Medical information needs efficient, robust and secure encryption modes, but cryptography is primarily a computationally intensive process. Towards this direction, we design a selective encryption scheme for critical data transmission. Methods: We expand the advandced encrytion stanard (AES)-Rijndael with five criteria: the first is the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089845
PubMed Central
- Sy, Adama; Barry, Aliou Hamady; Gaye, Mohamed; Sall, Abdou Salam; Driss, Ahmed
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title complex, [CoK2(C3H2O4)2(H2O)4]n, the Co atom is located on a position with site symmetry 2/m, the K atom and one water mol­ecule are located on a mirror plane, and the malonate and one water mol­ecule are located on a twofold rotation axis. The KI atom is seven-coordinated by four carboxyl­ate O atoms from four malonate ligands and by three water O atoms, forming a distorted...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089327
This article is from BMC Medical Research Methodology , volume 11 . Abstract Background: The prevailing view in therapeutic clinical research today is that observational studies are useful for generating new hypotheses and that controlled experiments (i.e., randomized clinical trials, RCTs) are the most appropriate method for assessing and confirming the efficacy of interventions. Discussion: The current trend towards patient-centered medicine calls for alternative ways of reasoning, and in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097156
PubMed Central
- Ahmad, Waqar; Ijaz, Bushra; Javed, Fouzia T; Gull, Sana; Kausar, Humaira; Sarwar, Muhammad T; Asad, Sultan; Shahid, Imran; Sumrin, Aleena; Khaliq, Saba; Jahan, Shah; Pervaiz, Asim; Hassan, Sajida
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This article is from BMC Gastroenterology , volume 11 . Abstract Background: Hepatitis C can lead to liver fibrosis and cirrhosis. We compared readily available non-invasive fibrosis indexes for the fibrosis progression discrimination to find a better combination of existing non-invasive markers. Methods: We studied 157 HCV infected patients who underwent liver biopsy. In order to differentiate HCV fibrosis progression, readily available AAR, APRI, FI and FIB-4 serum indexes were tested in the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098184
PubMed Central
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This article is from Annals of Indian Academy of Neurology , volume 14 . Abstract Attention-deficit/hyperactivity disorder (ADHD) is one of common neurodevelopmental disorder often comorbid with epilepsy. There are no existing guidelines on how to manage these two conditions when they are comorbid. To identify relationship between epilepsy and ADHD and to know role of antiepileptics and safety of stimulant like methylphenidate in such conditions from existing literature, we searched articles...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098523
PubMed Central
- Rodrigues, Vinola Z.; Foro, Sabine; Gowda, B. Thimme
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the centrosymmetric title compound, C20H24N2O6S2, the N—H and C=O bonds are trans to each other. In the crystal, inter­molecular N—H⋯O(S) hydrogen bonds link the mol­ecules into zigzag chains running along the b axis. The O atom involved in the hydrogen bond has a longer S—O bond than the other O atom bonded to S [1.441 (2) versus 1.428 (2) Å].
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099843
PubMed Central
- Rodrigues, Vinola Z.; Foro, Sabine; Gowda, B. Thimme
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the crystal of the title compound, C20H22Cl2N2O6S2, the asymmetric unit comprises half of a mol­ecule, the remaining portion is generated via an inversion centre. The conformation of the N—H and C=O bonds in the SO2–NH–C(O)–C segment is anti. The mol­ecule is bent at the S atom with the C–SO2–NH–C(O) torsion angle being 68.16 (19)°. The dihedral angle between the plane of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099798
PubMed Central
- Suleiman Gwaram, Nura; Saharin, Siti Munirah; Khaledi, Hamid; Mohd Ali, Hapipah
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This article is from Acta Crystallographica Section E: Structure Reports Online , volume 67 . Abstract In the title compound, [Ni(NCS)2(C11H17N3)(H2O)], the NiII ion is six-coordinated by the N,N′,N"-tridentate Schiff base N atoms, two cis-positioned N-bound isothio­cyanate groups and one water mol­ecule. In the crystal, O—H⋯S hydrogen bonds link adjacent mol­ecules into infinite layers parallel to the ac plane. The layers are further connected into a three-dimensional network via...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099768
PubMed Central
- Langley, Joanne M.; Risi, George; Caldwell, Michael; Gilderman, Larry; Berwald, Bruce; Fogarty, Charles; Poling, Terry; Riff, Dennis; Baron, Mira; Frenette, Louise; Sheldon, Eric; Collins, Harry; Shepard, Marc; Dionne, Marc; Brune, Daniel; Ferguson, Linda; Vaughn, David; Li, Ping; Fries, Louis
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This article is from The Journal of Infectious Diseases , volume 203 . Abstract Background. Highly pathogenic avian influenza H5N1 viruses remain a threat to human health, with potential to become pandemic agents.Methods. This phase III, placebo-controlled, observer-blinded study evaluated the immunogenicity, cross-reactivity, safety, and lot consistency of 2 doses of oil-in-water (AS03A) adjuvanted H5N1 A/Indonesia/05/2005 (3.75 μg hemagglutinin antigen) prepandemic candidate vaccine in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100510
This article is from Malaria Journal , volume 10 . Abstract Background: Malaria remains a serious problem in French Guiana, which is at potential risk for drought linked with the El Niño Event and where there could be a risk of malaria epidemic after the onset of an El Niño event. Methods: A time series analysis using ARIMA was developed to investigate temporal correlations between the monthly Plasmodium falciparum case numbers and El Niño Southern Oscillation (ENSO) as measured by the...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100257
PubMed Central
- Stroud, Robert Michael
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This article is from F1000 Biology Reports , volume 3 . Abstract The determination of membrane structures presents the structural biologist with many challenges; however, the last two years have seen major advances in our ability to resolve these structures at atomic resolution. My goal here is to summarize some of the most recent advances that have enhanced our prospects for understanding membrane proteins at the level of atomic structure.
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100781
PubMed Central
- Dhawan, D. K.; Chadha, Vijayta D.
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This article is from The Indian Journal of Medical Research , volume 132 . Abstract Proper intake of dietary nutrients is considered crucial for preventing the initiation of events leading to the development of carcinoma. Many dietary compounds have been considered to contribute in cancer prevention including zinc, which plays a pivotal role in host defense against the initiation and promotion of several malignancies. Zinc is an essential element that is integral to many proteins and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3102454
PubMed Central
- Allen, N E; Balkwill, A; Beral, V; Green, J; Reeves, G
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This article is from British Journal of Cancer , volume 104 . Abstract Background:: It has been suggested that the apparent protective effect of alcohol intake on renal cell carcinoma may be due to the diluting effect of carcinogens by a high total fluid intake. We assessed the association between intakes of total fluids and of specific beverages on the risk of renal cell carcinoma in a large prospective cohort of UK women. Methods:: Information on beverage consumption was obtained from a...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101943
PubMed Central
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This article is from Cell Death & Disease , volume 2 . Abstract Recent studies show that in Alzheimer's disease (AD), alterations in neurogenesis contribute to the neurodegenerative process. Neurodegeneration in AD has been associated with aberrant signaling through the cyclin-dependent kinase-5 (CDK5) pathway via its activators p35/p25; however, the role of CDK5 in the mechanisms of defective adult neurogenesis in AD is unknown. First, to study AD-like abnormal activation of CDK5 signaling...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101702
PubMed Central
- Ahmad, Amirozi; Mohamad, Irfan; Mansor, Suzana; Daud, Mohd Khairi; Sidek, Dinsuhaimi
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This article is from Annals of Saudi Medicine , volume 31 . Abstract BACKGROUND AND OBJECTIVE:: Universal newborn hearing screening (UNHS) was started in the Hospital Universiti Sains Malaysia (HUSM) in January 2003. To comply with international standards, we determined the outcome of the newborn hearing screening program for the first 5 years of its implementation, from January 2003 to December 2007. METHODS:: The program screened all infants who were delivered in HUSM. In a retrospective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101720
PubMed Central
- Yeh, Pei-Yen; Lu, Yen-Shen; Ou, Da-Liang; Cheng, Ann-Lii
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This article is from Molecular Cancer , volume 10 . Abstract Background: Both IκB kinase (IKK) complex and oncgenic protein Myc play important roles in cancer progression, including cancer cell invasiveness and metastasis. The levels of Myc is regulated by the phosphorylation of Myc at Thr58 and Ser62. Results: In this study, we show that the expression of Myc is associated with IKKα and IKKβ in breast cancers and that Myc is an IKKs substrate. Suppression of IKK activity by either chemical...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104363
This article is from The Open Biomedical Engineering Journal , volume 5 . Abstract It has now been known for over a decade that low frequency ultrasound can be used to effectively enhance transdermal drug penetration - an approach termed sonophoresis. Mechanistically, acoustic cavitation results in the creation of defects in the stratum corneum that allow accelerated absorption of topically applied molecules. The aim of this study was to develop an optimised sonophoresis protocol for studying...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103896
PubMed Central
- Koh, Liang-Piu; Poon, Michelle Li-Mei; Tam, John Kit-Chung; Teo, Lynette; Hsu, Li-Yang
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This article is from Mediterranean Journal of Hematology and Infectious Diseases , volume 3 . Abstract We report a case of invasive pulmonary aspergillosis (IPA) following respiratory syncytial virus infection in an allogeneic hematopoietic stem cell transplant (HSCT) recipient with chronic graft-versus-host disease. Delayed diagnosis of IPA resulted in the development of a pneumothorax, a rare consequence of fungal pneumonia. Respiratory virus infections are often harbingers of other infective...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103259
PubMed Central
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This article is from Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology , volume 7 . Abstract We herein present a patient with delayed-type allergic hypersensitivity against prilocaine leading to spreading eczematous dermatitis after subcutaneous injections for local anesthesia with prilocaine. Prilocaine allergy was proven by positive skin testing and subcutaneous provocation, whereas the evaluation of other local anesthetics...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104479
PubMed Central
- Ren, Yuantao; Yao, Xueqin; Dai, Hongmei; Li, Shulong; Fang, Hongqing; Chen, Huipeng; Zhou, Changlin
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This article is from Microbial Cell Factories , volume 10 . Abstract Background: Thymosin α1 (Tα1), a 28-amino acid Nα-acetylated peptide, has a powerful general immunostimulating activity. Although biosynthesis is an attractive means of large-scale manufacture, to date, Tα1 can only be chemosynthesized because of two obstacles to its biosynthesis: the difficulties in expressing small peptides and obtaining Nα-acetylation. In this study, we describe a novel production process for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103413
PubMed Central
- Karacaoren, Burak; Silander, Tomi; Alvarez-Castro, Jose M; Haley, Chris S; de Koning, Dirk Jan
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This article is from BMC Proceedings , volume 5 . Abstract Background: It has been shown that if genetic relationships among individuals are not taken into account for genome wide association studies, this may lead to false positives. To address this problem, we used Genome-wide Rapid Association using Mixed Model and Regression and principal component stratification analyses. To account for linkage disequilibrium among the significant markers, principal components loadings obtained from top...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103207
PubMed Central
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This article is from Indian Journal of Anaesthesia , volume 55 . Abstract A 1 year prospective analysis of all critically ill obstetric patients admitted to a newly developed dedicated obstetric intensive care unit (ICU) was done in order to characterize causes of admissions, interventions required, course and foetal maternal outcome. Utilization of mortality probability model II (MPM II) at admission for predicting maternal mortality was also assessed. During this period there were 16,756...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106387
PubMed Central
- Li, Yuqing; Li, Yi; Wedren, Sara; Li, Guoliang; Charn, Tze Howe; Desai, Kartiki Vasant; Bonnard, Carine; Czene, Kamila; Humphreys, Keith; Darabi, Hatef; Einarsdottir, Kristjana; Heikkinen, Tuomas; Aittomaki, Kristiina; Blomqvist, Carl; Chia, Kee Seng; Nevanlinna, Heli; Hall, Per; Liu, Edison T; Liu, Jianjun
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This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Given the role of estrogen in breast carcinogenesis and the modification of estrogen receptor (ER) activity by its biochemical cofactors, we hypothesize that genetic variation within ER cofactor genes alters cellular response to estrogen exposure and consequently modifies the risk for ER-positive breast cancer. Methods: We genotyped 790 tagging SNPs within 60 ER cofactor genes in 1,257 cases and 1,464...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109578
PubMed Central
- Rees, Johanna S.; Lowe, Nick; Armean, Irina M.; Roote, John; Johnson, Glynnis; Drummond, Emma; Spriggs, Helen; Ryder, Edward; Russell, Steven; Johnston, Daniel St; Lilley, Kathryn S.
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This article is from Molecular & Cellular Proteomics : MCP , volume 10 . Abstract Affinity purification coupled to mass spectrometry provides a reliable method for identifying proteins and their binding partners. In this study we have used Drosophila melanogaster proteins triple tagged with Flag, Strep II, and Yellow fluorescent protein in vivo within affinity pull-down experiments and isolated these proteins in their native complexes from embryos. We describe a pipeline for determining...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108830
PubMed Central
- Zaroo, Mohammed I.; Sheikh, Bashir A.; Wani, Adil H.; Darzi, Mohammad A.; Mir, Mohsin; Dar, Hameedullah; Baba Peerzada, U. F.; Zargar, Haroon R.
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This article is from Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India , volume 44 . Abstract Objective:: Hand burns are common injuries. Children frequently sustain burn injuries, especially to their hands. Contractures are a common sequel of severe burns around joints. The prepuce, or foreskin, has been used as a skin graft for a number of indications. We conducted this study to evaluate the feasibility of utilising the preputial skin for...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111128
PubMed Central
- Araujo, Lidiane S.; Kagohara, Edna; Garcia, Thais P.; Pellizari, Vivian H.; Andrade, Leandro H.
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This article is from Marine Drugs , volume 9 . Abstract Several microorganisms were isolated from soil/sediment samples of Antarctic Peninsula. The enrichment technique using (RS)-1-(phenyl)ethanol as a carbon source allowed us to isolate 232 psychrophile/psychrotroph microorganisms. We also evaluated the enzyme activity (oxidoreductases) for enantioselective oxidation reactions, by using derivatives of (RS)-1-(phenyl)ethanol as substrates. Among the studied microorganisms, 15...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111190
PubMed Central
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This article is from Journal of Indian Society of Periodontology , volume 14 . Abstract According to the literature, the prevalence of supernumerary teeth is 1% to 4% of permanent dentitions; and among these, the presence of fifth mandibular incisor — a supernumerary eumorphic tooth — has rarely been described in literature, and its association with localized aggressive periodontitis is an even more rare entity. This paper reports a very rare case of unusual association of supernumerary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110469
PubMed Central
- Pagani, Ioanna; Chertkov, Olga; Lapidus, Alla; Lucas, Susan; Del Rio, Tijana Glavina; Tice, Hope; Copeland, Alex; Cheng, Jan-Fang; Nolan, Matt; Saunders, Elizabeth; Pitluck, Sam; Held, Brittany; Goodwin, Lynne; Liolios, Konstantinos; Ovchinikova, Galina; Ivanova, Natalia; Mavromatis, Konstantinos; Pati, Amrita; Chen, Amy; Palaniappan, Krishna; Land, Miriam; Hauser, Loren; Jeffries, Cynthia D.; Detter, John C.; Han, Cliff; Tapia, Roxanne; Ngatchou-Djao, Olivier D.; Rohde, Manfred; Goker, Markus;...
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This article is from Standards in Genomic Sciences , volume 4 . Abstract Marivirga tractuosa (Lewin 1969) Nedashkovskaya et al. 2010 is the type species of the genus Marivirga, which belongs to the family Flammeovirgaceae. Members of this genus are of interest because of their gliding motility. The species is of interest because representative strains show resistance to several antibiotics, including gentamicin, kanamycin, neomycin, polymixin and streptomycin. This is the first complete genome...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111994
PubMed Central
- Dozmorov, Igor M.; Dresser, D.
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This article is from International Journal of Biomedical Science : IJBS , volume 6 . Abstract As suggested by the well-known gestalt concept the immune system can be regarded as an integrated complex system, the functioning of which cannot be fully characterized by the behavior of its constituent elements. Similar approaches to the immune system in particular and sensory systems in general allows one to discern similarities and differences in the process of distinguishing informative patterns...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113540
PubMed Central
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This article is from Nucleic Acids Research , volume 39 . Abstract The 279-bp major breakpoint region (mbr) within the 3′-untranslated region (3′-UTR) of the BCL2 gene is a binding site of special AT-rich sequence binding protein 1 (SATB1) that is well known to participate in the long-range regulation of gene transcription. Our previous studies have revealed that the mbr could regulate BCL2 transcription over a 200-kb distance and this regulatory function was closely related to SATB1. This...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113567
PubMed Central
- Liu, Huaping; Nishide, Daisuke; Tanaka, Takeshi; Kataura, Hiromichi
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This article is from Nature Communications , volume 2 . Abstract Monostructured single-wall carbon nanotubes (SWCNTs) are important in both scientific research and electronic and biomedical applications; however, the bulk separation of SWCNTs into populations of single-chirality nanotubes remains challenging. Here we report a simple and effective method for the large-scale chirality separation of SWCNTs using a single-surfactant multicolumn gel chromatography method utilizing one surfactant and...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113293
This article is from Trials , volume 12 . Abstract Background: The Acute Respiratory Distress Syndrome (ARDS) is a common cause of respiratory failure in critically ill patients. Experimental studies suggest that treatment with beta agonists may be helpful in ARDS. The Beta Agonist Lung Injury TrIal (BALTI-2) is a multicentre, pragmatic, randomised, double-blind, placebo-controlled clinical trial which aims to determine if sustained treatment with intravenous (IV) salbutamol will improve...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113985
This article is from Journal of Biomedical Science , volume 18 . Abstract Background: Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effects of HBO is poorly understood. We sought to investigate the cellular and molecular mechanisms of regulation of visfatin by HBO in human coronary arterial endothelial cells (CAECs). Methods: Human CAECs...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113732