Topics: DTIC Archive, Mehr, Z A, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *MALARIA,...
Reprint: Blood Gas and Acid-Base Status of Conscious Pigs Subjected to Fixed-Volume Hemorrhage and Resuscitated with Hypertonic Saline Dextran.
Topics: DTIC Archive, Hannon, John P, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Reprint: Sequential Changes in Alanine Metabolism Following Partial Hepatectomy in the Rat.
Topics: DTIC Archive, Klain, George J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
References to sanguivonous land leeches of the g. Haemadipsa are difficult to collect since they are poorly cross-referenced and are in obscure journals. We have published this bibliography to aid other investigators studying these leeches.
Topics: DTIC Archive, Wilson,H R, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Dextran metabolism was evaluated in euvolemic and hemorrhaged rabbits following administration of a 7.5%NaCl/6% Dextran-70 (HSD) solution. Control rabbits and those bled 8 ml/kg body weight were infused i.v. with 4 ml/kg of HSD or HSD containing C-Dextran-70. Blood samples were withdrawn prior to and at times up to 96 hr after HSD infusion. Peak serum dextran concentrations were about 29% higher in hemorrhaged rabbits than in controls, yet serum dextran t1/2 was similar in both groups....
Topics: DTIC Archive, Dubick, Michael A, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Reprint: Myopathic Alterations in Extraocular Muscle of Rats Subchronically Fed Pyridostigmine Bromide.
Topics: DTIC Archive, Schuschereba, Steven T, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Two important functions of blood are represented by the ability of red cells to reversibly bind and transport oxygen to the tissues and the ability of plasma proteins to maintain oncotic pressure. Because blood is a limited and valuable resource and has a relatively short storage life, several investigators have been attracted for many years to the development and evaluation of oxygen-carrying resuscitation solutions which could fulfill the functions of blood when administered for...
Topics: DTIC Archive, DeVenuto, Frank, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute dermal toxicity potential of 1-acetyloctahydro-3,5,7-trinitro-1,3,5,7-tetrazocine (SEX) was determined in rabbits by using abraded skin sites and plastic covering over the exposed areas for 24 hours. There were no compound-related deaths during this study.
Topics: DTIC Archive, Mullen,L, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *Toxicity,...
The acute oral toxicity of physostigmine salicylate was determined in male and female Hartley guinea pigs using the single dose method. The median lethal dose for both male and female guinea pigs was less than 7.1 mg/kg. Clinical signs observed were primarily related to changes in behavior; such as tremors, hypertonia, irritability, ataxia, and inactivity. Other frequently observed clinical signs included salivation, diarrhea, and lacrimation. The duration of the clinical signs was acute. Most...
Topics: DTIC Archive, Frost, Denzil F, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The explosives by-product, 1-acetyloctahydro-3,5,7-trinitro-1,3,5,7-tetrazine (SEX), was tested for primary dermal irritation potential on rabbits. The study was conducted in compliance with the Good Laboratory Practice Regulations. No erythema or edema was observed during the study; therefore, SEX was classified as a non-irritating chemical. (Author)
Topics: DTIC Archive, Lewis,Carolyn M, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of the Holston Compounds (Virgin DMSO DMSO Recycle Solvent, and DMSO Evaporator Sludge) was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Assay. Tester strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 were exposed to doses ranging from 0.1 ml of a 100% to ml of a 0.032% solution. Negative mutagenic responses were observed for the Virgin DMSO and DMSO Recycle Solvent. Mutgenic potential was observed for the DMSO Evaporator Sludge. (Author)
Topics: DTIC Archive, Sauers,Leonard J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
A spectrophotometric method for the quantitation of n-butyl 2-chloroethyl sulfide (BCS) has been developed using thymolphtalein as the chromogen. The chromophore produced by the reactants has a maximum absorbance at 444 millimicrons and absorbance is linear up to .000001 M BCS. This assay can provide quantitative measurements of the monofunctional mustard down to .000003 M.
Topics: DTIC Archive, Schmid,Peter, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *MUSTARD...
This Institute Report is a reproduction of the data and narrative analyses of personnel injury from Operation Just Cause.
Topics: DTIC Archive, McBride, Jr , John T, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Apparatus was constructed for the study of pursuit tracking in rhesus monkeys. Two rhesus were trained to track successfully a target moving at 5 milliradians (mrad) per sec (0.29 deg per sec) with an accuracy of + or - 7.5 mrad (0.43 deg) for 20 sec. For one monkey, vision was occluded for 1, 2, or 3 sec during a tracking trial. Tracking continued within 7.5 mrad from 0.48 to 3.24 sec. Additional keywords: visual motor tracking; vision blocking; vision occlusion. (Author).
Topics: DTIC Archive, Pribyl,V J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *TRACKING,...
Reprint: Relative Binding Constants of Arsenical-Antidote Adducts Determined by NMR Spectroscopy.
Topics: DTIC Archive, O'Connor, Richard J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
On February 28, 1991 the Combat Data Assessment Team (CDAT) from the US Army Medical Research and Development Command arrived in Frankfort, Germany. Their mission was to interview and to review the medical records of casualties who had been evacuated from Southwest Asia in Operation Desert Storm. The team interviewed 204 wounded soldiers and reviewed all available records. However, the team was located too far to the rear to obtain detailed information, and the information which was not...
Topics: DTIC Archive, Uhorchak, John M, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl) quinoline (CHR 5) was assessed by using the Ames salmonella/Mammalian Microsome Mutagenicity Assay. Tester strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 were exposed to doses ranging from .1 mg/plate to 3.2 x .00005 mg/plate. It was determined that the test substance did not have mutagenic potential.
Topics: DTIC Archive, Sauers,Leonard J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute oral toxicity potential of the explosives by-product, 1-acetyloctahydro-3,5,7-trinitro-1,3,5,7-tetrazocine (SEX) was determined in male and female albino Fisher 334 rats by using a single dose, free choice feeding method. The study was conducted in compliance with the Good Laboratory Practice Regulations. No compound related mortality was observed at a limit dose of 5.0 g/kg.
Topics: DTIC Archive, White,C W, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *TOXICITY,...
While ciliary rootlets have been reported in the inner segments of rods, little was known of their presence in the remainder of rhesus monkey rods and their presence in cones. In this study, we have observed striated rootlets in rhesus monkey rods and cones. The striated rootlet system in some rods and cones appears to form direct communication between the outer segments and the synapses. In addition, there are many complex associations, interconnections, and bridges between rootlet filaments...
Topics: DTIC Archive, Schuschereba,Steven T, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute oral toxicity of 4-nitrophenyl monochloromethyl (phenyl) phosphinate was determined in female, albino, Sprague-Dawley rats by using the single dose oral gavage method. LD1, LD50, and LD95 with the 95% confidence limits were calculated by probit analysis. The LD50 was 242 mg/kg with the 95% confidence limit (221 mg/kg, 265 mg/kg). The formulation falls in the very toxic range.
Topics: DTIC Archive, White, C W, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
One-half of deaths among trauma victims occur within 1 hour of injury and are due to rapid hemorrhage or CNS trauma. We developed a rapid hemorrhage model in unanesthetized swine to simulate human exsanguination. We compared the ability of four crystalloid solutions to prevent death after an otherwise fatal hemorrhage; normal saline (NS), Ringer's lactate (RL), Plasmalyte-A (PA), and Plasmalyte-R (PR). Five days before hemorrhage swine received an aortic sideport and a central venous treatment...
Topics: DTIC Archive, Traverso,L W, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *BLOOD...
Reprint: Wounding Effects of the AK-47 Rifle Used by Patrick Purdy in the Stockton, California, Schoolyard Shooting of January 17, 1989.
Topics: DTIC Archive, Fackler, Martin L, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Four repellents were field tested at Camp Lejeune, North Carolina using a newly developed four-site test method. Hexamethylene-carbamide and n-butane-hexamethyleneimime-sulfonamide were found to be significantly better than DEET, while triethylene-glycol ether was found to be only slightly less effective than DEET. The four-site field test method, was found to be an efficient screening method affording economical use of subjects. (Author)
Topics: DTIC Archive, Shimmin, Ronald, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The primary eye irritation potential of the Holston Compounds (Virgin DMSO, DMSO Recycle Solvent, and DMSO Evaporator Sludge) was tested by placing these materials in the conjunctival cul-de-sac of rabbit eyes. The study was conducted in compliance with the Good Laboratory Practice Regulations. All of the Dimethly Sulfoxide compounds tested produced irritation of the conjunctiva early in the study, but the level of severity did not meet the criteria for positive eye irritants.
Topics: DTIC Archive, Kellner,Thomas P, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The primary dermal irritation potential of DIGL-RP Solid Propellant was determined in female New Zealand White rabbits by using a modified Draize method. DIGL-RP was applied to two sites on the back of the rabbits for a 4-hour period. No skin reaction attributable to the test compound was detected at any time during the 14-day observation period. DIGL-RP Solid Propellant was a non- irritant under conditions of this study. (rrh)
Topics: DTIC Archive, Brown, Larry D, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of methyl N, N' dihexylethylene diamine monocarbamate (CHR4) and 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-ox o-2-butenyl) quinoline (CHR6) was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Assay. Tester strains TA 98, TA 100, TA 1535, TA 1537 and TA 1538 were exposed to doses ranging from 0.1% to 3.2 X 10 to the minus 5% of an undiluted sample of CHR4 and 1% to 3.2 X 10 to the minus 4% of an undiluted smaple of CHR6. Results of the Ames Assay...
Topics: DTIC Archive, Sauers,Leonard J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute intramuscular toxicity of MMB-4 was determined in male ICR mice by using the single dose method. LD(1), LD(50), and LD(95) with their 95% confidence limits were calculated by probit analysis. The LD(50) was 448 mg/kg with the 95% confidence limit (398 mg/kg, 506 mg/kg). The MMB-4 formulation falls in the very toxic range.
Topics: DTIC Archive, White, Craig W., LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of SEX and TAX was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Assay. Tester strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538 were exposed to doses ranging from 1 mg/plate to 10-5 mg/plate. Negative mutagenic responses were observed for both test compounds.
Topics: DTIC Archive, Kellner,T P, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute dermal toxicity potential of CHF1 and CHR2 was determined in rabbits using abraded skin sites and plastic covering over the exposed areas for 24 hrs. No animals died. Skin irritation was greatest in the flank regions, probably due to gravity accumulation and pressure due to skin folds and adhesive bandages. These compounds should be exposed to further toxicological testing for human use potential. (Author)
Topics: DTIC Archive, Hanes,Martha A, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Topics: DTIC Archive, Tombs, Michael P, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
1,25(OH)2D3 increases cell permeability to calcium. This increase is not mediated by proteins sensitive to cycloheximide or actinomycin D inhibition. We propose that CaBP may associate with intracellular membranes and organelles to prevent intracellular calcium accumulation and the potential cytotoxic effects of such accumulation. In support of this hypothesis, the amount of mitochondrial mineralization in chick intestinal cells was markedly increased by 1,25(OH)2D3 treatment when CaBP...
Topics: DTIC Archive, Morrissey, Robert L, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute dermal toxicity potential of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl) quinoline (CHR5) was determined in rabbits using abraded skin sites and plastic covering over the exposed areas for 24 hours. No animals died or showed clinical signs of toxicity. This compound should be exposed to further toxicological testing for human use potential. (Author)
Topics: DTIC Archive, Mullen,Lawrence, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
References to sanguivorous land leeches of the g. Haemadipsa are difficult to collect since they are poorly cross-referenced and are in obscure journals. We have prepared this review of conditions essential to laboratory colonization of the sanguivorous land leeches to aid other investigators studying these leeches. (Author)
Topics: DTIC Archive, Wilson,H Robert, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Topics: DTIC Archive, Elsayed, Nabil M, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The acute oral toxicity potential of CHF1 insect repellent was determined in rats by using the single dose method. LD1, LD50, and LD95 with their 95% confidence intervals were calculated by probit analysis. The LD50 for male rats was 4632 microliters/kg; the LD50 for female rats was 2495 microliters/kg. These results place the CHF1 formulation in the slightly toxic range. (Author)
Topics: DTIC Archive, Lewis,Carolyn M, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methyl-1-oxo-2-butenyl)quinoline (CHR5); 1,2,3,4-tetrahydro-6-methyl-1-(3-methyl-1-oxo-2-butenyl)quinoline (CHR6); 50% DEET, 25% Dow Corning 200 Fluid, in isopropanol (CHF1); was assessed using the Ames/Salmonella Mammalian Microsome Mutagenicity Assay. Tester strains TA 98, TA 100, TA 1535, TA 1537, and TA 1538, were exposed to 1 u1/plate through .000032 u1/plate doses of CHR5 and CHR6 and 0.1 u1/plate through .000032 u1/plate...
Topics: DTIC Archive, Sauers,Leonard J, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The potential for diethyleneglycol dinitrate (DEGDN) to produce primary eye irritation was evaluated in six male New Zealand White rabbits by using a modified Draize method. DEGDN produced no response indicative of a potential to cause irritation upon direct contact with the eye. Slight iridial vasodilation (one of six rabbits) and slight conjunctival vasodilation and swelling, indicative of mild inflammation, (three of six rabbits) were the most serious responses observed. DEGDN was classified...
Topics: DTIC Archive, Hiatt, Gerald F, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Most users of ordnance gelatin for ballistics studies are apparently unaware of the detrimental effects on this tissue simulant's properties caused by excess heating in reconstitution of the gelatin powder. Material published by the Gelatin Manufacturers Institute of America, Inc., states that heating gelatin above 40 C can be detrimental to its properties. The manufacturer of type 250 A Ordnance Gelatin does not include directions for preparation with the gelatin powder. Directions that can be...
Topics: DTIC Archive, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *HEATING, *WOUNDS AND...
Two levels of protein (200 and 100 gm/day) were fed to two groups of young adults who exercised strenuously for 40 days. From body volume, total body water mass, 40 K whole body counting, and potassium balances, it was determined that the 2.10 kg gain in body weight in Group I subjects (200 gm of protein/day) reflected 0.67, 2.42, and 0.22 kg gains of dry protein, water, and mineral, respectively, with a 1.21 kg loss of body fat. Lesser gains of 0.39 kg of dry protein, 1.46 kg of body water,...
Topics: DTIC Archive, Krzywicki, Harry J., LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Nitroguanidine was tested for its potential to produce sensitization via contact with the skin. Testing on male guinea pigs was performed using the Buehler Dermal Sensitization Method. No evidence of dermal sensitization to nitroguanidine was obtained in this study. Keywords: Toxicology, Toxicity.
Topics: DTIC Archive, Morgan, Earl W, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
4-Nitrophenyl methly (phenyl) phosphinate (tw011) is being considered as a prophylactic agent in anticholinesterase poisoning. This compound was tested for mutagenic activity using Drosophila melanogaster Sex-Linked Recessive Lethal assay. It was found non-mutagenic after 72-hour feeding exposures to 0.002 and 0.0025 mM of tw011.
Topics: DTIC Archive, Powers,Nelson R, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The mutagenic potential of NITROGUANIDINE was assessed by using the Ames Salmonella/Mammalian Microsome Mutagenicity Test. Tester strains TA97, TA98, TA100, TA102, TA1535, TA1537, and TA1538 were exposed to doses ranging from 2.8 mg/plate to 0.0875 mg/plate. The test compound was not mutagenic under conditions of this test. Keywords: Genetic toxicology, Ames test.
Topics: DTIC Archive, Sebastin, Suzanne E, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
We developed a fixed-volume porcine hemorrhage model that simulates the rapid exsanguination of combat or civilian trauma victims. In this study we compared the ability of five resuscitation solutions to prevent death after an otherwise lethal hemorrhage in 100 swine. The shed blood was replace in a 1:1 with either autologous whole blood (WB), untyped swine-fresh frozen plasma (FFP), type FFP, 5 percent human serum albumin (ALB), or normal saline (NS). survival rate analysis indicated that WB...
Topics: DTIC Archive, Traverso,L W, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *BLOOD...
Niclosamide, the active ingredient in a schistosome topical antipenetrant lotions, was tested for its potential to produce dermal sensitization. The guinea pig maximization test was used to evaluate dermal sensitization potential. Grade III (moderate) dermal sensitization to the niclosamide was obtained in this study. These results suggest that there is probable risk that the active ingredient in the schistosome topical antipenetrant lotion will induce contact sensitivity in humans. Dermal...
Topics: DTIC Archive, Frost, Denzil F, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The insect repellents methyl N,N'-dihexylethlenendiamine-monocarbamate (CHR4), (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methly-1-oxo-2-butenyl) quinoline (CHR5), and 1,2,3,4-tetrahydro-6-methly-1-(3-methly-1-oxo-2-butenyl) quinoline (CHR6) were tested for ocular irritation potential using Primary Eye Irritation Test on rabbits. The study was conducted in compliance with the Good Laboratory Practice regulations. Of the three repellents tested, only CHR4 was shown to be a positive ocular irritant....
Topics: DTIC Archive, Kellner,Thomas P, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
A modified Draize test was used to determine the level of primary dermal irritation attributable to the physical abrasion resulting from the wiping action needed for decontamination with the Prototype M-258A-1 Decontamination Kit. Exposure sites were not occluded. Scores were below those considered to be caused by a primary irritant. (Author)
Topics: DTIC Archive, Fruin,John T, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Four repellents were tested under different climatic conditions found at Turtle Mound, Florida; Fort Wainwright, Alaska; and Colusa, California. Test repellents cyclo-hexamethylene-carbamide and n-butane-hexamethyleneimine- sulfonamide were found to protect as long as or longer than N, N-diethyl-m- toluamide, the standard military repellent, under all test conditions at equal concentrations. Trioxa-pentadecan-1-01 was statistically no different from deet. Mild temperatures in Alaska compared to...
Topics: DTIC Archive, Spencer, T. S., LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
Phosphate paraoxon was studied in Yorkshire pig, rat and human sera. Enzymatic hydrolysis was significantly affected by certain buffers in the reaction mixture. Kinetic measurements suggest that more than one enzyme hydrolyzes the organophosphate. Depending on pH and substrate concentration, inhibition of the enzymes by paraoxon is or is not observed. Enzymatic activity in human serum increases with a rise in pH whereas in pig serum activity decreases. (Author)
Topics: DTIC Archive, Schmid,Peter, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA, *POISONS,...
The acute oral toxicity potential of triethylene glycol monohexyl ether (CHR9) a cadidate insect repellent, was tested in male and female rats exposed to dose levels ranging from vehicle control to 10 ml/kg body weight. Animals were single dosed and observed for 14 days. Only one female rat died during the observation period. No male rats died. There are no LD50 calculation or time of death curves for this study, due to the low toxicity of this chemical. The compound is considered practically...
Topics: DTIC Archive, Mullen,Lawrence, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
The primary dermal irritation potential of diethylene glycol dinitrate (DEGDN) was determined in New Zealand White rabbits using a modified Draize procedure. The test compound was classified as a nonirritant following a 4-hour application period. Neither edema, erythema, nor any other recognizable skin reaction was detected at any time during the 72-hour observation period. Primary dermal irritation, Diethyleneglycol dinitrate, DEGDN, Rabbit, Munitions.
Topics: DTIC Archive, Brown, Larry D, LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA,...
